UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934
(Amendment No. )
Filed by the Registrant ☒
Filed by a Party other than the Registrant ☐
Check the appropriate box:
☐ |
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Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) Soliciting Material Pursuant to §240.14a-12 SYROS PHARMACEUTICALS, INC. (Name of Registrant as Specified in Its Charter) (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant) Payment of Filing Fee (Check the appropriate box): ☒ No fee ☐ Fee paid previously with preliminary 0-11 ☐☐ ☒ ☒ Definitive Proxy Statement☐ ☐ Definitive Additional Materials☐ Soliciting Material Pursuant to §240.14a-12☐ required.requiredFee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.(1)Title of each class of securities to which transaction applies:(2)Aggregate number of securities to which transaction applies:(3)Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):(4)Proposed maximum aggregate value of transaction:(5)Total fee paid:☐materials.materials☐ ☐Check box if any part of the fee is offset as providedFee computed on table in exhibit required by Item 25(b) per Exchange Act Rule 0-11(a)(2)Rules 14a-6(i)(1) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.(1)Amount previously paid:(2)Form, Schedule or Registration Statement No.:(3)Filing Party:(4)Date Filed:
SYROS PHARMACEUTICALS, INC.
620 Memorial35 CambridgePark Drive, Suite 300
4th Floor, Cambridge, Massachusetts 0213902140
(617) 744-1340
NOTICE OF 20172023 ANNUAL MEETING OF STOCKHOLDERS
To Be Held on June 8, 2017
1, 2023
Dear Stockholders:
You are cordially invited to attend the 20172023 annual meeting of stockholders of Syros Pharmaceuticals, Inc. toThe meeting will be held virtually via the Internet at www.meetnow.global/MQZFQ4S on Thursday, June 8, 20171, 2023 at 1:9:00 p.m.a.m., Eastern Daylight Time, at our corporate offices located at 620 Memorial Drive, Suite 300, Cambridge, Massachusetts 02139. Time.
At the annual meeting, stockholders will consider and vote on the following matters:
1. | The election of |
2. | The ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, |
3. | The approval, on a non-binding advisory basis, of the compensation of our named executive officers; and |
| 4. | The transaction of any other business that may properly come before the annual meeting or any adjournment or postponement thereof. |
As noted above, our annual meeting will be a “virtual meeting” of stockholders, which will be conducted exclusively via the Internet. There will not be a physical meeting location, and stockholders will not be able to attend the annual meeting in person. This means that you can attend the annual meeting online, vote your shares during the online meeting and submit questions for consideration prior to and during the online meeting, all by following the instructions described in the accompanying proxy statement. Stockholders of record at the close of business on April 13, 20174, 2023 will be entitled to notice of and to vote at the annual meeting or any adjournment or postponement thereof. We believe that hosting a “virtual meeting” will enable greater stockholder attendance and participation from any location around the world.
This Notice, the accompanying proxy statement and a form of proxy card are being mailed beginning on or about April 21, 2023 to all stockholders entitled to vote at the annual meeting. We have elected to provide access to our proxy materials over the Internet under the Securities and Exchange Commission’s “notice and access” rules. We believe that providing our proxy materials over the Internet expedites stockholders’ receipt of proxy materials, lowers costs and reduces the environmental impact of our annual meeting.
We encourage all stockholders to attend the annual meeting in person.online. However, whether or not you plan to attend the annual meeting in person,online, we encourage you to read this proxy statement and submit your proxy or voting instructions as soon as possible. Please review the instructions on each of your voting options described in the proxy statement.
Thank you for your ongoing support and continued interest in Syros.
By Order of the Board of Directors,
Nancy A. Simonian, M.D.
President and Chief Executive Officer
Cambridge, Massachusetts
April 25, 201721, 2023
Important Notice Regarding Internet Availability of Proxy Materials: The attached proxy statement and our 20162022 annual report to stockholders, which includes our Annual Report on Form 10-K for the fiscal year ended December 31, 2016,2022, are available atwww.envisionreports.com/SYRS. These documents are also available to any stockholder who wishes to receive a paper copy by calling (866) 641-4276, by emailing investorvote@computershare.com with “Proxy Materials Syros Pharmaceuticals, Inc.” in the subject line, or by submitting a request over the Internet at www.envisionreports.com/SYRS.
SYROS PHARMACEUTICALS, INC.
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620 Memorial35 CambridgePark Drive, Suite 300
4th Floor, Cambridge, Massachusetts 0213902140
(617) 744-1340
PROXY STATEMENT
20172023 ANNUAL MEETING OF STOCKHOLDERS
To Be Held on June 8, 20171, 2023
INFORMATION CONCERNING SOLICITATION AND VOTING
This proxy statement and the enclosed proxy card are being furnished in connection with the solicitation of proxies by the board of directors of Syros Pharmaceuticals, Inc. for use at the annual meeting of stockholders to be held on Thursday, June 8, 20171, 2023 at 1:9:00 p.m.a.m., Eastern Daylight Time, at our corporate offices located at 620 Memorial Drive, Suite 300, Cambridge, Massachusetts 02139, and at any adjournment thereof. The meeting will be held virtually via the Internet at www.meetnow.global/MQZFQ4S. You will be able to attend and participate in the annual meeting online, vote your shares electronically and submit your questions prior to and during the meeting, all by following the instructions described in this proxy statement in the section entitled “Important Information About the Annual Meeting and Voting.” There will not be a physical meeting location, and stockholders will not be able to attend the annual meeting in person. Except where the context otherwise requires, references to “Syros Pharmaceuticals,” “the Company,” “we,” “us,” “our” and similar terms refer to Syros Pharmaceuticals, Inc.
This proxy statement summarizes information about the proposals to be considered at the meeting and other information you may find useful in determining how to vote. The proxy card is the means by whichhow you actually authorize another person to vote your shares in accordance with your instructions. We are making this proxy statement, the related proxy card and our annual report to stockholders for the fiscal year ended December 31, 20162022 available to stockholders for the first time on or about April 25, 2017.21, 2023.
A copy of our Annual Report on Form 10-K for the fiscal year ended December 31, 2016,2022, as filed with the Securities and Exchange Commission, or SEC, except for exhibits, will be furnished without charge to any stockholder upon written or oral request to Syros Pharmaceuticals, Inc., 620 Memorial35 CambridgePark Drive, Suite 300,4th Floor, Cambridge, Massachusetts 0213902140 or by calling (866) 641-4276, by emailing investorvote@computershare.com with “Proxy Materials Syros Pharmaceuticals, Inc.” in the subject line, or by submitting a request over the Internet at www.envisionreports.com/SYRS. This proxy statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 20162022 are also available on the SEC’s website atwww.sec.gov.
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IMPORTANT INFORMATION ABOUT THE ANNUAL MEETING AND VOTING
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A. Our board of directors has made these materials available to you on the Internet in connection with the solicitation of proxies for use at our 2017 annual meeting of stockholders to be held at our corporate offices located at 620 Memorial Drive, Suite 300, Cambridge, Massachusetts 02139 on Thursday, June 8, 2017 at 1:00 p.m.
A. | Our board of directors has made these materials available to you on the Internet in connection with the solicitation of proxies for use at our 2023 annual meeting of stockholders to be held virtually at www.meetnow.global/MQZFQ4S on Thursday, June 1, 2023 at 9:00 a.m., Eastern Daylight Time. As a holder of common stock, you are invited to attend the annual meeting online and are requested to vote on the items of business described in this proxy statement. This proxy statement includes information that we are required to provide to you under |
Q.Why did I receive a notice in the mail regarding the Internet availability of proxy materials instead of a full set of proxy materials?
A. In accordance with SEC rules, we may furnish proxy materials, including this proxy statement and our 2016 annual report, to our stockholders by providing access to such documents on the Internet instead of mailing printed copies. If you would like to receive a paper copy of our proxy materials, you should follow the instructions for requesting such materials in the notice.
Q.What is the purpose of the annual meeting?
A. At the annual meeting, stockholders will consider and vote on the following matters:
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A. | In accordance with SEC rules, we may furnish proxy materials, including this proxy statement and our 2022 annual report, to our stockholders by providing access to such documents on the Internet instead of mailing printed copies. If you would like to receive a paper copy of our proxy materials, you should follow the instructions for requesting such materials in the notice. |
Q. | What is the purpose of the annual meeting? |
A. | At the annual meeting, stockholders will consider and vote on the following matters: |
1. | The election of |
2. | The ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, |
3. | The approval, on a non-binding advisory basis, of the compensation of our named executive officers (Proposal 3); and |
| 4. | The transaction of any other business that may properly come before the annual meeting or any adjournment or postponement thereof. |
Q. | Why is the 2023 annual meeting a virtual, online meeting? |
Q.Who can vote
A. | Our 2023 annual meeting will be a virtual meeting of stockholders where stockholders will participate by accessing a website using the Internet. There will not be a physical meeting location. We believe that hosting a virtual meeting will facilitate stockholder attendance and participation at our 2023 annual meeting by enabling stockholders to safely participate remotely from any location around the world. We have designed the virtual annual meeting to provide the same rights and opportunities to participate as stockholders have at an in-person meeting, including the right to vote and ask questions through the virtual meeting platform. |
Q. | How do I attend the annual meeting virtually? |
A. | The annual meeting will be a completely virtual meeting of stockholders, which will be conducted exclusively by webcast. No physical meeting will be held. You are entitled to participate in the annual meeting only if you were a stockholder of record as of the close of business on April 4, 2023, the record date for our annual meeting, or if you hold a valid legal proxy for the annual meeting. |
You will be able to attend the annual meeting?
A. Tomeeting online and submit your questions during the meeting by visiting www.meetnow.global/MQZFQ4S. You also will be entitledable to vote your shares online by attending the annual meeting by webcast.
To participate in the annual meeting, you will need to review the information included on your notice, on your proxy card or on the instructions that accompanied your proxy materials.
If you hold your shares through an intermediary, such as a bank or broker, you must have beenregister in advance using the instructions below under “How do I register to attend the virtual annual meeting?”.
The online meeting will begin promptly at 9:00 a.m., Eastern Daylight Time. We encourage you to access the meeting fifteen to thirty minutes prior to the start time to allow for ample time for the check in. Please follow the registration instructions as outlined in this proxy statement.
Q. | How do I register to attend the virtual annual meeting? |
A. | If you are a “record holder” of our shares (i.e., you hold your shares through our transfer agent, Computershare Trust Company, N.A.), you do not need to register to attend the virtual annual meeting. Please follow the instructions on the notice or proxy card that you received. |
If you hold your shares through an intermediary, such as a stockholderbank or broker, you must register in advance to attend the virtual annual meeting.
To register to attend the annual meeting online by webcast you must submit proof of record at the closeyour proxy power (legal proxy) reflecting your holdings of business on April 13, 2017, the record date for our annual meeting. There were 23,449,986 shares of our common stock outstandingalong with your name and entitledemail address to vote atComputershare. A legal proxy is not the annual meetingform of proxy included with this proxy statement. Requests for registration must be labeled as “Legal Proxy” and be received no later than 5:00 p.m., Eastern Daylight Time, on Friday, May 26, 2023.
You will receive a confirmation of the record date.your registration by email after we receive your registration materials.
Requests for registration should be directed to Computershare as follows:
Q.How many votes do I have?
By email: | Forward the email from your broker, or attach an image of your legal proxy, to | |
legalproxy@computershare.com. | ||
By mail: | Computershare | |
Syros Pharmaceuticals, Inc. Legal Proxy | ||
P.O. Box 43001 | ||
Providence, RI 02940-3001 |
A. Each share of our common stock that you own as of the record date will entitle you to one vote on each matter considered at the annual meeting.
Q. | What if I have trouble accessing the annual meeting virtually? |
The virtual meeting platform is fully supported across MS Edge, Firefox, Chrome and Safari browsers and devices (desktops, laptops, tablets and cell phones) running the most up-to-date version of applicable software and plug-ins. Please note that Internet Explorer is not supported. Participants should ensure that they have a strong WiFi connection wherever they intend to participate in the meeting. We encourage you to access the meeting fifteen to thirty minutes prior to the start time. A link on the meeting page will provide further assistance should you need it or you may call 1-888-724-2416 or 1-781-575-2748. Who can vote at the annual meeting? To be entitled to vote, you must have been a stockholder of record at the close of business on April 4, 2023, the record date for our annual meeting. There were 20,409,130 shares of our common stock outstanding and entitled to vote at the annual meeting as of the record date. The list of our stockholders of record will be available, via link on the meeting page (www.meetnow.global/MQZFQ4S), during the annual meeting. In addition, we will make available a list of stockholders of record as of the record date for inspection by stockholders for any purpose germane to the annual meeting during the ten days preceding the annual meeting. To access the stockholder list during this time, please send your request, and proof of ownership, to our corporate secretary at 35 CambridgePark Drive, 4th Floor, Cambridge MA 02140, attention: Corporate Secretary. How many votes do I have? Each share of our common stock that you own as of the record date will entitle you to one vote on each matter considered at the annual meeting.Q.How do I vote?A. A. If you are the “record holder” of your shares, meaning that your shares are registered in your name in the records of our transfer agent, Computershare Trust Company, N.A., you may vote your shares at the meeting in person or by proxy as follows:Q. A. Q. A.
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A. | If you are the “record holder” of your shares, meaning that your shares are registered in your name in the records of our transfer agent, Computershare Trust Company, N.A., you may vote your shares at the virtual meeting or by proxy as follows: |
1. | Over the |
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your proxy by telephone. You must specify how you want your shares voted or your Internet vote cannot be completed, and you will receive an error message. You must submit your Internet proxy before |
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If your shares are held in “street name,” meaning they are held for your account by an intermediary, such as a broker, then you are deemed to be the beneficial owner of your shares and the broker that actually holds the shares for you is the record holder and is required to vote the shares it holds on your behalf according to your instructions. The proxy materials, as well as voting and revocation instructions, should have been forwarded to you by the broker that holds your shares. In order toTo vote your shares, you will need to follow the instructions that your broker provides you. Many brokers solicit voting instructions over the Internet or by telephone.
If you do not give instructions to your broker, your broker will still be able to vote your shares with respect to certain “discretionary” items. The ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm (Proposal 2) is considered a discretionary item. Accordingly, your broker may vote your shares in its discretion with respect to that matter even if you do not give voting instructions on Proposal 2.
However, under applicable stock exchange rules that regulate voting by registered brokerage firms, the election of our nominees to serve as Class I directors (Proposal 1) isand the advisory vote on the compensation paid to our named executive officers (Proposal 3) are not considered to be a discretionary item.items. Accordingly, if you do not give your broker voting instructions on Proposal 1 or Proposal 3, your broker may not vote your shares with respect to this matterthese matters and your shares will be counted as “broker non-votes” with respect to the proposal.these proposals. A “broker non-vote” occurs when shares held by a broker are not
voted with respect to a particular proposal because the broker does not have or did not exercise discretionary authority to vote on the matter and has not received voting instructions from its clients.
Regardless of whether your shares are held in street name, you are welcome to attend the meeting.meeting online. You may not vote shares held in street name in person atduring the virtual meeting, however, unless you obtain a legal proxy, executed in your favor, from the holder of record (i.e., your broker) and register for the meeting in advance as described above under “How do I register to attend the virtual annual meeting?”. A legal proxy is not the form of proxy included with this proxy statement.
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Q. | Can I change my vote? |
Q.Can I change my vote?
A. | If your shares are registered directly in your name, you may revoke your proxy and change your vote at any time before the vote is taken at the annual meeting. To do so, you must do one of the following: |
A. If your shares are registered directly in your name, you may revoke your proxy and change your vote at any time before the vote is taken at the annual meeting. To do so, you must do one of the following:
1. | Vote over the Internet or by telephone as instructed |
2. | Sign and return a new proxy card. Only your latest dated and timely received proxy card will be counted. |
3. | Attend the virtual annual meeting and vote |
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If your shares are held in “street name,” you may submit new voting instructions by contacting your broker or other nominee. You may also vote in person atonline during the annual meeting if you obtain a legal proxy and register in advance to attend the meeting, as described inabove under “How do I register to attend the answer above.virtual annual meeting?”.
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A. | A majority of our shares of common stock outstanding at the record date must be present virtually or represented by proxy to hold the annual meeting. This is called a quorum. For purposes of determining whether a quorum exists, we count as present any shares that are voted over the Internet, by telephone, by completing and submitting a proxy card by mail or that are represented virtually at the meeting. Further, for purposes of establishing a quorum, we will count as present shares that a stockholder holds even if the stockholder votes to abstain or only votes on one of the proposals. In addition, we will count as present shares held in “street name” by brokers who indicate on their proxies that they do not have authority to vote those shares. If a quorum is not present, we expect to adjourn the annual meeting until we obtain a quorum. |
Q. | What vote is required to approve each matter and how are votes counted? |
A. | Proposal 1—Election of Class I Directors |
For the annual meeting?
A. A majorityelection of our shares of common stock outstanding at the record date must be present in persondirectors, you may vote “for” or represented by proxy to hold the annual meeting. This is called a quorum. For purposes of determining whether a quorum exists, we count as present any shares that are voted over the Internet, by telephone, by completing and submitting a proxy card by mail or that are represented in person at the meeting. Further,“withhold” for purposes of establishing a quorum, we will count as present shares that a stockholder holds even if the stockholder votes to abstain or only votes on one of the proposals. In addition, we will count as present shares held in “street name” by brokers who indicate on their proxies that they do not have authority to vote those shares. If a quorum is not present, we expect to adjourn the annual meeting until we obtain a quorum.
Q.What vote is required to approve each matter and how are votes counted?
A. Proposal 1—Election of Class I Directors
director nominee. A nominee will be elected as a director at the annual meeting if the nominee receives a plurality of the votes cast “for” the applicable seat on the board of directors.
“Withhold” votes will have no impact on the number of votes cast “for” an applicable seat on the board of directors.
Proposal 2—Ratification of the Appointment of Independent Registered Public Accounting Firm
The affirmative vote of the holders of shares of common stock representing a majority of the votes cast on the matter is required forFor the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ended December 31, 2017. 2023, you may vote “for,” “against” or “abstain.” To approve Proposal 2, holders of a majority of the votes cast on the matter must vote FOR the proposal.
Although stockholder approval of our audit committee’s appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ended December 31, 2023 is not required, we believe that it is advisable to give stockholders an opportunity to ratify this appointment. If this proposal is not approved at the annual meeting, our audit committee will reconsider its appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ended December 31, 2023.
Proposal 3—Advisory Vote on the Compensation Paid to Named Executive Officers
For the advisory vote on the compensation paid to our named executive officers, you may vote “for,” “against” or “abstain.” To approve Proposal 3, holders of a majority of the votes cast on the matter must vote FOR the proposal. Proposal 3 is non-binding. Because this vote is advisory and not binding on us or our board in any way, our board may decide that it is in our and our stockholders’ best interests to compensate our named executive officers in an amount or manner that differs from that which is approved by our stockholders.
Shares that abstain from voting and “broker non-votes” with respect to a matter will not be counted as votes in favor of such matter and will also not be counted as shares voting on such matter. Accordingly, abstentions and “broker non-votes” will have no effect on the voting on Proposal 1 referenced above, and abstentions and “broker non-votes” will have no effect on the voting on Proposal 2 or Proposal 23 referenced above.
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Q. | How does the board of directors recommend that I vote on the proposals? |
A. | Our board of directors recommends that you vote: |
Q.How does the board of directors recommend that I vote on the proposals?
A. Our board of directors recommends that you vote:
FOR the election of the threefour nominees to serve as Class I directors, each for a three yearthree-year term; and
FOR the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2017.2023; and
FOR the approval, on an advisory (non-binding) basis, of the compensation of our named executive officers.
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A. We do not know of any matters that may come before the annual meeting other than the election of our Class I directors and the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm.
A. | We do not know of any matters that may come before the annual meeting other than the election of our Class I directors, the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm, and the approval of the compensation of our named executive officers. If any other matters are properly presented at the annual meeting, the persons named in the accompanying proxy intend to vote, or otherwise act, in accordance with their judgment on the matter. |
Q.Where can I find the voting results?
Q. | How do I submit a question at the annual meeting? |
A. We plan to announce preliminary voting results at the annual meeting and will report final voting results in a Current Report on Form 8-K filed with the SEC within four business days
A. | You will be able to attend the annual meeting online and submit your questions during the meeting by visiting www.meetnow.global/MQZFQ4S, as further described above under “How do I attend the virtual annual meeting?”. Questions pertinent to meeting matters will be answered during the meeting, subject to time constraints. The meeting is not to be used as a forum to present personal matters, or general economic, political or other views that are not directly related to our business and the matters properly before the meeting, and therefore questions on such matters will not be answered. All questions received from stockholders before or during the virtual annual meeting will be posted on our website at ir.syros.com as soon as practicable following the |
Q. | Where can I find the voting results? |
We plan to announce preliminary voting results at the annual meeting and will report final voting results in a Current Report on Form 8-K filed with the SEC within four business days following the date of our annual meeting. What are the costs of soliciting these proxies? We will bear the cost of soliciting proxies. In addition to solicitation by mail, our directors, officers and employees may solicit proxies by telephone, e-mail, facsimile, and in person without additional compensation. We may reimburse brokers or persons holding stock in their names, or in the names of their nominees, for their expenses in sending proxies and proxy material to beneficial owners. Implications of Being We are Q.What are the costs of soliciting these proxies?A. A. We will bear the cost of soliciting proxies. In addition to solicitation by mail, our directors, officers and employees may solicit proxies by telephone, e-mail, facsimile, and in person without additional compensation. We may reimburse brokers or persons holding stock in their names, or in the names of their nominees, for their expenses in sending proxies and proxy material to beneficial owners.Q. A. an “Emerging Growtha “Smaller Reporting Company”an “emerging growtha “smaller reporting company,” as defined in Rule 12b-2 under the Jumpstart Our Business StartupsSecurities Exchange Act of 2012, or the JOBS Act,1934, as amended (the “Exchange Act”). The SEC has adopted rules allowing smaller reporting companies to provide scaled disclosure, and may remain an emerging growth company for up to five years from the date of our initial public offering, or IPO. The JOBS Act contains provisions that, among other things, reduce certain reporting requirements for an “emerging growth company.” For so long as we remain an emerging growth company, we are permitted and plan to rely on these exemptions from certain disclosure requirements thatfor as long as we remain a smaller reporting company. We are applicable to othera smaller reporting company so long as we have a public companies that are not emerging growth companies. These exemptions include reducedfloat of less than $250 million, or have annual revenues of less than $100 million and a public float less than $700 million, determined on an annual basis. Under the scaled disclosure obligations regarding executive compensation. In addition, as an emerging growth company,available to smaller reporting companies, we are not required to conduct votes seeking approval, on an advisory basis, of the compensation of our namedprovide, among other things, Compensation Discussion and Analysis and certain other tabular and narrative disclosures relating to executive officers or the frequency with which such votes must be conducted. We may take advantage of some or all these exemptions until such time as we are no longer an emerging growth company. We would cease to be an emerging growth company if we have more than $1 billion in annual revenue, we have more than $700 million in market value of our stock held by non-affiliates or we issue more than $1 billion of non-convertible debt over a three-year period.compensation. We have taken advantage of certain reduced reporting obligations in this proxy statement. Accordingly, the information contained herein may be different than the information you receive from other public companies in which you hold stock.
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BOARD OF DIRECTORS AND CORPORATE GOVERNANCE
Election of Directors
Our board of directors is divided into three classes, with members of each class holding office for staggered three-year terms. There are currently four Class I directors (Stéphane Bancel, Amir Nashat, Ph.D., Robert T. Nelsen(Mark J. Alles, Andrew M. Oh, Timothy C. Tyson, and Peter Wirth), whose terms expire at this annual meeting of stockholders;stockholders, three Class II directors (Vicki L. Sato,(Srinivas Akkaraju, M.D., Ph.D., Phillip A. Sharp, Ph.D.Deborah Dunsire, M.D., and Richard A. Young, Ph.D.), whose terms expire at the 20182024 annual meeting of stockholders;stockholders, and three Class III directors (Marsha(S. Gail Eckhardt, M.D., Marsha H. Fanucci Sanj K. Patel and Nancy A. Simonian, M.D.), whose terms expire at the 20192025 annual meeting of stockholders (in all cases subject to the election and qualification of their successors or to their earlier death, resignation or removal). Mr. Bancel will not be standing for re-election toWe believe that our classified board structure:
enhances the effectiveness of our board by helping ensure that, at any given time, a majority of directors at this annual meeting of stockholders,have experience and familiarity with our business; and
promotes continuity and stability on our board, which is not a result of any disagreement between Mr. Bancel and our companyallows it to focus on any matter relatinglong-term planning intended to our operations, policies or practices. Messrs. Bancel and Nelsen and Dr. Nashat were elected as directors pursuant to a voting agreement that we entered into with the holders of our preferred stock that terminated upon the closing of our IPO. enhance stockholder value.
Set forth below are the names of and certain information for each member of our board, including the nominees for election as Class I directors, as of April 1, 2017.March 31, 2023. The information presented includes each director’s and nominee’s principal occupation and business experience for the past five years, and the names of other public companies of which he or she has served as a director during the past five years. The information presented below regarding the specific experience, qualifications, attributes and skills of each director and nominee led our nominating and corporate governance committee and our board of directors to conclude that he or she should
serve as a director. In addition, we believe that all of our directors and nominees possess the attributes or characteristics described in “Corporate Governance Matters—Director Nomination Process” that the nominating and corporate governance committee expects of each director. There are no family relationships among any of our directors, nominees for director, or executive officers.
Name | Age | Position(s) | ||||||
Class I Director Nominees | ||||||||
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| 63 | Director | |||||
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| 52 | Director | |||||
Timothy C. Tyson (2) | 70 | Director | ||||||
Peter Wirth |
| 72 | Chair of the Board of Directors | |||||
Class II Directors | ||||||||
| 55 | Director | ||||||
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| 60 |
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Richard A. Young, Ph.D. (3)(4) |
| 69 | Director | |||||
Class III Directors | ||||||||
| 65 | Director | ||||||
Marsha H. Fanucci (1) |
| 69 |
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| Director |
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Nancy A. Simonian, M.D. |
| 62 | President and Chief Executive Officer, Director |
(1) | Member of the audit committee. |
(2) |
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(3) | Member of the nominating and corporate governance committee. |
| (4) | Member of the |
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Class I Director Nominees
Amir Nashat, Ph.D.Mark J. Alles has served on our board of directors since January 2016.December 2019. Mr. Alles served as chief executive officer of Celgene Corporation, a global biopharmaceutical company, or Celgene, from March 2016 to June 2018 and as its chairman and chief executive officer from February 2018 until its acquisition by Bristol-Myers Squibb Company in November 2019. Prior to these roles, Mr. Alles served as Celgene’s president and chief operating officer from August 2014 to February 2016 and as its chief commercial officer and executive vice president, hematology & oncology from December 2012 to July 2014. Mr. Alles first joined Celgene in April 2004 and served in a number of commercial management positions of increasing responsibility at the company. Before joining Celgene, he held senior commercial management roles at Aventis Pharmaceuticals Inc. (Rhône-Poulenc Rorer) from 1993 to 2004. He is a managing partner at Polaris Partners, a venture capital firm, where he has worked since 2002. Dr. Nashat alsocurrently serves on the board of the Partners Innovation Fund and the MIT Sandbox Innovation Fund Program. Dr. Nashat serves on the boards of directors of aTyr Pharma, Inc., Fate Therapeutics, Inc.Antengene Corporation Limited and Selecta Biosciences, Inc., allBioMarin Pharmaceuticals, both public biopharmaceutical companies. He previously served on the boardscompanies, and of directors of Bind Therapeutics, Inc. and Receptos, Inc., eachTORL BioTherapeutics LLC, a biopharmaceuticalprivate life sciences company. Dr. NashatMr. Alles received a Ph.D. in chemical engineeringB.S. degree from the Massachusetts Institute of Technology, and an M.S. and B.S. in materials science and mechanical engineering from theLock Haven University of California, Berkeley.Pennsylvania and served as a Captain in the United States Marine Corps. We believe Dr. NashatMr. Alles is qualified to serve on our board of directors becausedue to his extensive executive experience and his track record of building successful global oncology organizations and commercializing innovative therapies.
Andrew M. Oh has served on our board of directors since September 2022.He has been a Senior Partner at Flagship Pioneering, or Flagship, since January 2021. He previously served as Chief Financial Officer of Rubius Therapeutics, Inc. from December 2017 to September 2020. Prior to joining Rubius, Mr. Oh served as the Co-Founder, Director, Chief Investment Officer and Chief Operating Officer of Leerink Pharmaceutical Investments, a private asset management company focused on investing in public healthcare stocks, from January 2014 to December 2017. From May 2006 to March 2013, Mr. Oh served as the Senior Global Pharmaceutical Analyst at Fidelity Investments and as the Portfolio Manager overseeing the Fidelity Select Pharmaceuticals Portfolio fund. Mr. Oh received an M.B.A. from Northwestern University’s Kellogg School of Management and a B.A. in Biology from Washington University in St. Louis. Mr. Oh was first elected to our board as the designee of Flagship following the closing of a private placement in September 2022. We believe Mr. Oh is qualified to
serve on our board of directors due to his expertise with public and financial accounting matters, his experience on the boards of directors of other publicly-tradedleading financial organizations in biotechnology companies, and his experience as an investor in biotechnology and life sciences companies.
Robert T. NelsenTimothy C. Tyson has served on our board of directors since our inceptionSeptember 2022. He served as Chairman and CEO of Avara Pharmaceutical Services from May 2015 to October 2018. He served as Chief Executive Officer and Executive Chairman of Aptuit from 2008 to 2012 and non-executive Chairman from 2012 to 2016. Mr. Tyson served as the Chief Executive Officer of Valeant Pharmaceuticals International (formerly, ICN Pharmaceuticals Inc.) from 2005 to 2008. He served as President of Valeant Pharmaceuticals International from 2002 to 2008 and served as its Chief Operating Officer from 2002 to 2004. He served as President of Global Manufacturing and Supply for GlaxoSmithKline plc. from 1998 to 2002. From 1997 to 1998, Mr. Tyson served as GlaxoSmithKline’s Vice President and General Manager of Business Operations. During his 14-year tenure at GlaxoSmithKline, he served in November 2011a variety of roles with broad international and domestic responsibilities, including significant management experience running two divisions: Glaxo Dermatology and Cerenex Pharmaceuticals. Prior to his tenure at GlaxoSmithKline, Mr. Tyson served in a number of executive positions at Bristol-Myers Company in Operations and Research and Development. Before his tenure at Bristol-Myers, he served as a Manufacturing Manager for Procter & Gamble. He served as an Officer in the United States Army from 1974 to 1979 and spent 14 years in the United States Army Reserves. Mr. Tyson was a member of the board of directors of Tyme Technologies, Inc., or Tyme, from March 2015 until its acquisition by Syros in September 2022, and was first elected to our lead independent director from December 2015board as the designee of Tyme pursuant to January 2017. Mr. Nelsen was a co-founderthe terms of ARCH Venture Partners, a venture capital firm, and has served in various capacities for ARCH and affiliated entities since 1986.the acquisition. He is currently Chairman and CEO of TriRx Pharmaceutical Services, LLC and Chairman at Icagen Inc. Mr. Tyson received a managing director of ARCH Venture Corporation. Mr. NelsenMaster in Business Administration and Master in Public Administration from Jacksonville State University in 1979 and 1976, respectively. He is also a director of Agios Pharmaceuticals, Inc. and Juno Therapeutics, Inc., each a biopharmaceutical company. Mr. Nelsen previously served as a trustee1974 graduate of the Fred Hutchinson Cancer Research Institute, a trustee of the Institute for Systems Biology, and a director of the National Venture Capital Association. He has also served as a director of the following biopharmaceutical companies: Bellerophon Therapeutics, Inc., Fate Therapeutics, Inc., Kythera Biopharmaceuticals, Inc. and NeurogesX, Inc. Mr. Nelsen received a B.S. with majors in biology and economics from the University of Puget Sound and an M.B.A. from the University of Chicago.United States Military Academy at West Point. We believe Mr. NelsenTyson is qualified to serve on our board of directors due to his significant operational and senior management experience in the pharmaceutical industry, as well as his extensive experience as an investor in,a director on public and director of, early stage biopharmaceutical and life sciences companies. private boards.
Peter Wirth has served as Chair of our board of directors since January 2017. Mr. Wirth has been a Venture Partner with Quan Capital Management, a venture capital firm, since August 2018, and currently serves as Chairmana director of FORMA Therapeutics Holdings LLC, a privately-held small molecule drug discovery company, Executive Chairman of ZappRx, Inc., a privately-held digital health company, Senior Advisor to Zai Lab Limited, a privately-heldpublicly traded biopharmaceutical company, based in Shanghai, China, and as a director at Kira Pharmaceuticals, Inc., a privately held biotechnology company, and previously served as a director of Aura Biosciences,Forma Therapeutics Holdings, Inc., a privately-held biopharmaceutical company. From November 2011 to April 2014, Mr. Wirth served as President and director of Lysosomal Therapeutics, Inc., a privately-heldpublic biopharmaceutical company. Mr. Wirth was a senior executive at Genzyme Corporation, or Genzyme, from 1996 until after its acquisition by Sanofi-Aventis in 2011, most recently serving as Executive Vice President, Legalexecutive vice president, legal and Corporate Development, Chief Risk Officercorporate development, chief risk officer and Corporate Secretary.corporate secretary. During his time at Genzyme, Mr. Wirth had senior management responsibility for the company’s legal function, corporate development function, molecular oncology division, polymer drug discovery and development division and enterprise risk management function. Mr. Wirth previously served as a director of Synageva BioPharma Corp. a biopharmaceutical company. Mr. Wirth was a 2012 Advanced Leadership Fellow at Harvard University. He received his B.A. from the University of Wisconsin-Madison and his J.D. from Harvard Law School. We believe Mr. Wirth is qualified to serve on our board of directors due to his expertise in corporate governance and his experience in corporate strategy, product development and law in the biotechnology industry.
Class I Director Not Standing for Re-Election
Stéphane Bancel has served as a member of our board of directors since November 2013. He has been president, founding chief executive officer and a director of Moderna Therapeutics Inc., a privately-held biotechnology company, since July 2011. Mr. Bancel was previously chief executive officer of bioMérieux SA, a publicly-traded diagnostics company, from 2006 to July 2011. Prior to his time at bioMérieux, Mr. Bancel was managing director of Eli Lilly in Belgium and executive director of global manufacturing strategy and supply chain at Eli Lilly in Indianapolis, Indiana. Mr. Bancel currently serves as a supervisory director of Qiagen N.V., a molecular diagnostics company. Mr. Bancel holds an M.E. from École Central Paris, an M.S. in chemical engineering from the University of Minnesota and an M.B.A. from Harvard Business School.
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Class II Directors
Vicki L. Sato,Srinivas Akkaraju, M.D., Ph.D. has served on our board of directors since August 2013. SheJune 2017. Dr. Akkaraju is a founder and managing general partner of Samsara BioCapital, a venture capital firm, a position he has been a professor of management practice at Harvard Business Schoolheld since September 2006 and was a professor in the Department of Molecular and Cell Biology at Harvard University from July 2005 until October 2015. Previously, sheMarch 2017. From April 2013 to February 2016, Dr. Akkaraju served as presidenta general partner of VertexSofinnova Ventures, a venture capital firm. Dr. Akkaraju received an M.D. and a Ph.D. in immunology from Stanford University and undergraduate degrees in biochemistry and computer science from Rice University. Dr. Akkaraju serves as a director of Intercept Pharmaceuticals, Inc., Chinook Therapeutics, Inc., and Scholar Rock Holding Corporation, each a publicly-tradedpublicly traded biotechnology company, which she joined in 1992. Prior to becoming president of Vertex, she was the chief scientific officer and senior vice president of research and development. Prior to joining Vertex, Dr. SatoJiya Acquisition Corp., a publicly traded special purpose acquisition company. Previously, he served as vice presidenta director of research at BiogenAravive, Inc., aTyr Pharma, Inc., Principia Biopharma Inc., and Seattle Genetics, Inc., each a publicly-tradedpublicly traded biotechnology company. Dr. Sato is a member of the boards of directors of the following public companies: Bristol Myers Squibb Company, PerkinElmer Corporation and BorgWarner, Inc. Dr. Sato received her A.B. from Radcliffe College and her A.M. and Ph.D. degrees from Harvard University. She conducted her postdoctoral work at both the University of California Berkeley and Stanford Medical Center. We believe Dr. SatoAkkaraju is qualified to serve on our board of directors because of herhis strong scientific background and extensive experience as a senior executivein private equity and as a director of several life sciences companies, and because of her knowledge of our industry.venture capital investing.
Phillip A. Sharp, Ph.D.Deborah Dunsire, M.D. has served on our board of directors since December 2012.September 2021. Dr. SharpDunsire is President and Chief Executive Officer of H. Lundbeck A/S, a public biopharmaceutical company, a position she has been an institute professor at the Massachusetts Instituteheld since September 2018. She previously served as President and Chief Executive Officer and a Director of Technology since 1999. Much of Dr. Sharp’s scientific work has been conducted at MIT’s Center for Cancer Research (now the Koch Institute), which he joined in 1974 and directed from 1985 to 1991. He subsequently led the Department of Biology from 1991 to 1999 before assuming the directorship of the McGovern Institute from 2000 to 2004. Dr. Sharp is the winner of the 1993 Nobel Prize in Physiology or Medicine. Dr. Sharp has served on the board of directors of AlnylamXtuit Pharmaceuticals, Inc., a private biopharmaceutical company, since 2002. He earned his B.A. from Union College (Kentucky) in 1966January 2017 to March 2018. Prior to her position at Xtuit, she served as President and Chief Executive Officer and a Ph.D. in chemistryDirector of FORUM Pharmaceuticals Inc., a private pharmaceutical company, from July 2013 to May 2016. Prior to FORUM, Dr. Dunsire worked for Takeda Pharmaceutical Company Limited as a corporate officer from June 2010 to June 2011 and a Director from June 2011 to June 2013. She served as President, Chief Executive Officer and a Director of Millennium Pharmaceuticals, Inc. between 2005 and 2008, when it was acquired by Takeda, and then as President and Chief Executive Officer of Millennium: The Takeda Oncology Company after the acquisition between 2008 and 2013. Prior to Millennium, Dr. Dunsire held various roles of increasing responsibility at Novartis Pharma AG between 1988 and 2005. She currently serves as a Board member of Ultragenyx Pharmaceutical Inc, a public biopharmaceutical company. She obtained an MBBCh from the University of Illinois, Champaign Urbanathe Witwatersrand in 1969. He did his postdoctoral training at the California Institute of Technology.South Africa. We believe Dr. SharpDunsire is qualified to serve on our board of directors due to his scientific expertiseher extensive experience in the biotechnology and his experiencepharmaceutical sectors, including service as a directorthe chief executive officer of a publicly traded company.various pharmaceutical companies.
Richard A. Young, Ph.D. has served on our board of directors since our inception in November 2011. He is also one of our scientific co-founders and a member of our scientific advisory board. He has been a memberMember of the Whitehead Institute and professorProfessor of Biology at MIT since 1984 and an Affiliate Member of the MassachusettsBroad Institute of Technology since 1984. In May 2012, he2004. He was elected into the National Academy of Sciences.Sciences in 2012 and the National Academy of Medicine in 2019. Dr. Young has served as an advisor to Science magazinethe National Institutes of Health and the World Health Organization. Dr. Young previously served as a directorcurrently serves on the board of Enzon Pharmaceuticals,directors of Omega Therapeutics, Inc., a biopharmaceuticalpublic biotechnology company, and on the boards of directors of Camp4 Therapeutics, Inc., Dewpoint Therapeutics, Inc. and Paratus Sciences, Inc., each a private biotechnology company. Dr. Young received his Ph.D. in molecular biophysics and biochemistry from Yale University. We believe Dr. Young is qualified to serve on our board of directors because of his scientific expertise and his role as one of our scientific co-founders.
Class III Directors
S. Gail Eckhardt, M.D. has been a member of our board of directors since September 2020. Dr. Eckhardt is a tenured Professor, inaugural Director of the Livestrong Cancer Institutes, Chair of the Department of Oncology, and Associate Dean of Cancer Programs at the University of Texas at Austin’s Dell Medical School, or UT Austin. She has been a faculty member at the institution since January of 2017. Prior to joining UT Austin, Dr. Eckhardt was at the University of Colorado School of Medicine from 1999 to January 2017, where she had numerous roles and responsibilities, including Division Head of Medical Oncology, Associate Director for Translational Research at the University of Colorado Comprehensive Cancer Center and Director of the Phase I Program and Fellowship. Dr. Eckhardt has also served on numerous committees and study sections, including the ASCO Molecular Oncology Task Force, the ASCO Board of Directors, the FDA Oncology Drugs Advisory Committee, and the National Cancer Institute (NCI) Cancer Centers Study Section. She is a member of the NCI Investigational Drug Steering Committee and serves on several external advisory boards of NCI-designated cancer centers, was a lead mentor in ASCO’s Leadership Development Program and currently is a member of the Board of Directors of the Association of American Cancer Institutes. Dr. Eckhardt earned her B.S. degree in chemistry from Stephen F. Austin State University and her M.D. from the University of Texas Medical Branch in Galveston. She conducted her internship and residency in Internal Medicine at the University of Virginia Medical School, followed by a post-doctoral research fellowship in Experimental and Molecular Medicine at Scripps Research Institute in La Jolla, California, and a fellowship in Medical Oncology at the University of California San Diego. We believe Dr. Eckhardt is qualified to serve on our board of directors due to her expertise in the preclinical and early clinical development of novel agents and her extensive drug development experience.
Marsha H. Fanucci has been a member of our board of directors since October 2015. Since 2009, Ms. Fanucci has been an independent consultant. From 2004 throughto 2009, she served as senior vice president and chief financial officer of Millennium Pharmaceuticals, Inc., a biopharmaceutical company, or Millennium, that
was subsequently acquired by Takeda Pharmaceuticals Company, a publicly traded biopharmaceutical company, or Takeda. She previously served in various other roles at Millennium, including as vice president, finance and corporate strategy and vice president, corporate development. Ms. Fanucci is a member of the boards of directors of Alnylam Pharmaceuticals, Inc. and Ironwood Pharmaceuticals,Cyclerion Therapeutics, Inc., each a publicly-tradedpublicly traded biopharmaceutical company. She previously served as a director of Momenta Pharmaceuticals, Inc., Ironwood Pharmaceuticals, Inc., and Forma Therapeutics Holdings, Inc., each a publicly-tradedpublicly traded biopharmaceutical company. Ms. Fanucci received her B.S. in pharmacy from West Virginia University and her M.B.A. from Northeastern University. We believe Ms. Fanucci is qualified to serve on our board of directors due to her expertise with public and financial accounting matters and her experience leading financial organizations in biotechnology companies.
Sanj K. Patel has served on our board of directors since May 2016. Mr. Patel is the founder, chief executive officer and chairman of Kiniksa Pharmaceuticals, Ltd., a privately-held biotechnology company. Before founding Kiniksa in June 2015, Mr. Patel was the president and chief executive officer and a director of Synageva BioPharma Corp. from June 2008 until its acquisition by Alexion, Inc. in June 2015. From 1999 to 2008, Mr. Patel worked at Genzyme Corporation, where most recently he was the head of U.S. sales, marketing and commercial operations for
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Genzyme Therapeutics’ Lysosomal Storage Disorder franchise. Previously, Mr. Patel held several cross functional senior leadership roles at Genzyme, including vice president, clinical research and head of the Global Clinical Research Operations Council. Prior to Genzyme, Mr. Patel held roles in clinical research and commercial development with increasing levels of responsibility at Burroughs Wellcome, a private foundation; Hoechst Marion Roussel, a privately-held life sciences company; and Fujisawa Pharmaceutical Co. Ltd., a privately-held pharmaceutical company. Mr. Patel is a member of the board of directors of BioCryst Pharmaceuticals, Inc., a biotechnology company. Mr. Patel obtained his B.Sc. with honors in biotechnology from the University of the South Bank, London. He completed his post graduate management and business degree, and doctorate level research program at Ealing College, London, and the Wellcome Foundation, respectively. We believe Mr. Patel is qualified to serve as a director based on his extensive healthcare industry leadership experience.
Nancy A. Simonian, M.D.has been our chief executive officer since July 2012. From 2001 to October 2011, Dr. Simonian was employed by Takeda Pharmaceuticals Company, a publicly-held biopharmaceutical company, and at Millennium, Pharmaceuticals, Inc. prior to its acquisition by Takeda, most recently serving as chief medical officer and senior vice president of clinical, medical and regulatory affairs. From 1995 to 2001, Dr. Simonian served at Biogen, Inc., a publicly-heldpublicly traded biotechnology company, and most recently served as vice president of clinical development. She is a member of the boardsboard of directors of Seattle Genetics,Seagen Inc., a publicly traded biopharmaceutical company, Alltrna, Inc., a private biotechnology company, the Damon Runyon Cancer Research Foundation and the Biotechnology Industry Organization. She previously served as a member of the board of directors of Evelo Biosciences, Inc. from April 2018 to June 2021. Prior to joining the biopharmaceutical industry, Dr. Simonian was on the faculty of Massachusetts General Hospital and Harvard Medical School as an assistant professor of neurology. She received a B.A. in biology from Princeton University and an M.D. from the University of Pennsylvania School of Medicine. We believe Dr. Simonian is qualified to serve on our board of directors because of her role as our chief executive officer, her experience in the biopharmaceutical industry and her other executive leadership and board of directors experience.
Our board of directors believes that good corporate governance is important to ensure that our company is managed for the long-term benefit of stockholders. This section describes key corporate governance guidelines and practices that our board of directors has adopted. Complete copies of our corporate governance guidelines, committee charters and code of conduct are available on the “News“Investors & Investors—Corporate Media—Governance” section of our website, which is located at www.syros.com. Alternatively, you can request a copy of any of these documents by writing us at Syros Pharmaceuticals, Inc., 620 Memorial35 CambridgePark Drive, Suite 300,4th Floor, Cambridge, Massachusetts 02139,02140, Attention: Chief OperatingFinancial Officer.
Corporate Governance Guidelines
Our board of directors has adopted corporate governance guidelines to assist in the exercise of its duties and responsibilities and to serve the best interests of our company and our stockholders. These guidelines, which provide a framework for the conduct of our board of directors’ business, provide that:
| the principal responsibility of our board of directors is to oversee our management; |
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a majority of the members of the board of directors must be independent directors, unless otherwise permitted by Nasdaq rules; |
| the independent directors meet at least twice a year in executive session; |
| directors have full and free access to management and, as necessary and appropriate, independent advisors; and |
| new directors participate in an orientation program and all directors are expected to participate in continuing director education on an ongoing basis. |
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Board Leadership Structure
Our corporate governance guidelines provide that the nominating and corporate governance committee shall periodically assess the board of directors’ leadership structure, including whether the offices of chief executive officer and chair of the board of directors should be separate. Our guidelines provide the board of directors with flexibility to determine whether the two roles should be combined or separated based upon our needs and the board of directors’ assessment of its leadership from time to time. We currently separate the roles of chief executive officer and chair of the board of directors. OurDr. Simonian, as our president and chief executive officer, is responsible for setting the strategic direction for our company and the for providing day-to-day leadership and performance of our company, while theMr. Wirth, as chair of our board of directors, presides over meetings of the board of directors, including executive sessions of the board of directors, and performs oversight responsibilities. We do not currently have a lead independent director because the chair of our board of directors is independent within the meaning of the NASDAQ listing rules.Nasdaq Listing Rules. Our board of directors has three standing audit, compensation and nominating and corporate governance committees that currently consist of, and are chaired by, independent directors. Our board of directors delegates substantial responsibilities to the committees, which then report their activities and actions back to the full board of directors. We believe that the independent committees of our board of directors and their chairpersons promote effective independent governance. We believe this structure currently represents an appropriate allocation of roles and responsibilities for our company at this time because it strikes an effective balance between management and independent leadership participation in our board of directors proceedings.
Board Determination of Independence
Rule 5605 of the NASDAQNasdaq Listing Rules requires a majority of a listed company’s board of directors to be comprised of independent directors within one year of listing. In addition, the NASDAQNasdaq Listing Rules require that, subject to specified exceptions, each member of a listed company’s audit, compensation and nominating and corporate governance committees be independent under the Securities Exchange Act of 1934, as amended, or the Exchange Act. Audit committee members must also satisfy the independence criteria set forth in Rule 10A-3 under the Exchange Act, and compensation committee members must also satisfy the independence criteria set forth in Rule 10C-1 under the Exchange Act. Under Rule 5605(a)(2) of the NASDAQNasdaq Listing Rules, a director will only qualify as an “independent director” if, in the opinion of our board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. In order to be considered independent for purposes of Rule 10A-3, a member of an audit committee of a listed company may not, other than in his or her capacity as a member of the audit committee, the board of directors, or any other board committee, accept, directly or indirectly, any consulting, advisory, or other compensatory fee from the listed company or any of its subsidiaries or otherwise be an affiliated person of the listed company or any of its subsidiaries. In order to be considered independent for purposes of Rule 10C-1, the board must consider, for each member of a compensation committee of a listed company, all factors specifically relevant to determining whether a director has a relationship to such company which is material to that director’s ability to be independent from management in connection with the duties of a compensation committee member, including, but not limited to: (1) the source of compensation of the director, including any consulting advisory or other compensatory fee paid by such company to the director; and (2) whether the director is affiliated with the company or any of its subsidiaries or affiliates.
Our board of directors undertook a review of the composition of our board of directors and its committees and the independence of each director. Based upon information requested from and provided by each director concerning his or her background, employment and affiliations, including family relationships, our board of directors has determined that each of our directors other than Dr. Simonian is an “independent director” as defined under Rule 5605(a)(2) of the NASDAQNasdaq Listing Rules. Dr. Simonian is not an independent director under Rule 5605(a)(2) because she is our Presidentpresident and Chief Executive Officer.chief executive officer. Our board of directors also determined that Mark J. Alles, Marsha H. Fanucci, Amir Nashat, Ph.D. and Sanj K. Patel,Andrew M. Oh, who currently comprise our audit committee, Phillip A. Sharp, Ph.D.Deborah Dunsire, M.D., Robert T. NelsenTimothy C. Tyson, and Peter Wirth, who currently comprise our compensation committee, and Vicki L. Sato,Srinivas Akkaraju, M.D., Ph.D., Stéphane BancelS. Gail Eckhardt, M.D., and Amir Nashat,Richard Young, Ph.D., who
currently comprise our nominating and corporate governance committee, satisfy the independence standards for such committees established by the SEC and the NASDAQNasdaq Listing Rules, as applicable, including in the case of all members of the audit committee, the independence requirements contemplated by Rule 10A-3 under the Exchange Act and, in the case of all members of the compensation committee, the independence requirements contemplated by Rule 10C-1 under the Exchange Act. In addition, our board of directors determined that Richard A. Young,Amir Nashat, Ph.D., who served
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on the audit committee and the nominating and corporate governance committee for part of 2016,until September 2022, and Stéphane Bancel and Vicki L. Sato,Phillip A. Sharp, Ph.D., who served on the compensation committee for part of 2016,until September 2022, at the timestime of such service, satisfied the applicable independence standards for such committees. In making such determinations, our board of directors considered the relationships that each such non-employee director has with our company and all other facts and circumstances our board of directors deemed relevant in determining independence, including the beneficial ownership of our capital stock by each non-employee director.
Board Diversity Matrix (as of March 31, 2023)
Board Size: | ||||||||||||||||
Total Number of Directors | 10 | |||||||||||||||
Female | Male | Non-binary | Did not Disclose Gender | |||||||||||||
Gender: |
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Directors | 4 | 6 | 0 | 0 | ||||||||||||
Number of Directors who identify in Any of the Categories Below: |
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African American or Black | 0 | 0 | 0 | 0 | ||||||||||||
Alaskan Native or Native American | 0 | 0 | 0 | 0 | ||||||||||||
Asian | 0 | 2 | 0 | 0 | ||||||||||||
Hispanic or Latinx | 0 | 0 | 0 | 0 | ||||||||||||
Native Hawaiian or Pacific Islander | 0 | 0 | 0 | 0 | ||||||||||||
White | 4 | 4 | 0 | 0 | ||||||||||||
Two or More Races or Ethnicities | 0 | 0 | 0 | 0 | ||||||||||||
Member of the LGBTQ+ Community | 0 | 0 | 0 | 0 | ||||||||||||
Did Not Disclose | 0 | 0 | 0 | 0 |
Board of Director Meetings and Attendance
Our board of directors held sixfourteen meetings and acted by written consent five times, during the year ended December 31, 2016,2022, or fiscal 2016.2022. During fiscal 2016,2022, each of the directors then in office other than Srinivas Akkaraju, M.D., Ph.D., attended at least 75% of the aggregate of the number of board of director meetings and the number of meetings held by all committees of the board of directors on which such director then served. Dr. Akkaraju attended 71% of the aggregate number of board of director meetings and the number of meetings held by the committees of the board of directors on which he then served. Our corporate governance guidelines provideset out an expectation that directors are expected to attend the annual meeting of stockholders. Seven of the ten directors who were then serving on our board of directors attended our 2022 annual meeting of stockholders.
Communicating with the Independent Directors
TheOur board of directors will give appropriate attention to written communications that are submitted by stockholders and will respond if and as appropriate. The chair of the board of directors is primarily responsible for monitoring communications from stockholders and for providing copies or summaries to the other directors as he considers appropriate.
Communications are forwarded to all directors if they relate to important substantive matters and include suggestions or comments that the chair of the board considers to be important for the directors to know. In general, communications relating to corporate governance and corporate strategy are more likely to be forwarded than communications relating to ordinary business affairs, personal grievances and matters as to which we receive repetitive or duplicative communications.
Stockholders who wish to send communications on any topic to our board of directors should address such communications to Syros Pharmaceuticals, Inc., Attention: Board of Directors, 620 Memorial35 CambridgePark Drive, Suite 300,4th Floor, Cambridge, Massachusetts 02139.02140.
Committees of the Board of Directors
We have established an audit committee, a compensation committee, and a nominating and corporate governance committee, and a research and development committee. Each of these committees operates under a charter that has been approved by our board of directors. A copy of each committee’s charter can be found under the “News“Investors & Investors—Corporate Media—Governance” section of our website, which is located at www.syros.com.
Audit Committee
Our audit committee’s responsibilities include:
| appointing, approving the compensation of, and assessing the independence of our registered public accounting firm; |
| overseeing the work of our independent registered public accounting firm, including through the receipt and consideration of reports from such firm; |
| reviewing and discussing with management and our independent registered public accounting firm our annual and quarterly financial statements and related disclosures; |
| monitoring our internal control over financial reporting, disclosure controls and procedures and code of business conduct and ethics; |
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overseeing our internal audit function, if any; |
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overseeing our risk assessment and risk management policies; |
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establishing procedures for the receipt and retention of accounting related complaints and concerns; |
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meeting independently with our internal auditing staff, if any, our independent registered public accounting firm and management; |
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reviewing and approving or ratifying any related person transactions; and |
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preparing the audit committee report required by SEC rules.
The current members of our audit committee are Mark J. Alles, Marsha H. Fanucci Amir Nashat, Ph.D. and Sanj K. Patel.Andrew M. Oh. Ms. Fanucci chairs the audit committee. Our board of directors has determined that Ms. Fanucci qualifies as an “audit committee financial expert” within the meaning of applicable SEC rules. Richard A. YoungAmir Nashat, Ph.D., served on the auditthis committee from January tountil September 2016.2022. The audit committee held threefive meetings during fiscal 2016.2022.
Compensation Committee
Our compensation committee’s responsibilities include:
| reviewing and approving, or making recommendations to our board with respect to, the compensation of our chief executive officer and other executive officers; |
| overseeing the evaluation of our senior executives; |
| overseeing and administering our cash and equity incentive plans; |
reviewing and making recommendations to our board of directors with respect to director compensation and management succession planning; reviewing and discussing annually with management our “Compensation Discussion and Analysis” disclosure if and to the extent such disclosure is then required by SEC rules; and |
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preparing the compensation committee report if and to the extent then required by SEC rules. |
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To the extent permitted by and consistent with applicable law and the provisions of a given equity-based plan, the
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compensation committee may delegate to one or more of our executive officers the power to grant options or other stock awards pursuant to an equity-based plan to our employees who are not directors or executive officers.
The current members of our compensation committee are Phillip A. Sharp, Ph.D.Deborah Dunsire, M.D., Robert T. NelsenTimothy C. Tyson, and Peter Wirth. Dr. SharpMr. Wirth chairs the compensation committee. Stéphane Bancel served on the compensation committee from January to September 2016, and Vicki L. Sato,Philip A. Sharp, Ph.D. served on this committee from January 2016 to January 2017.until September 2022. The compensation committee held eightnine meetings during fiscal 2016.2022.
Nominating and Corporate Governance Committee
Our nominating and corporate governance committee’s responsibilities include:
| identifying individuals qualified to become members of our board of directors; |
| recommending to our board the persons to be nominated for election as directors and to each of our board’s committees; |
| reviewing and making recommendations to our board of directors with respect to our board leadership structure and board committee structure; |
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making recommendations to our board of directors with respect to accepting director resignations; |
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developing and recommending to our board corporate governance principles; and |
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overseeing an annual evaluation of our board.
The current members of our nominating and corporate governance committee are Vicki L. Sato,Srinivas Akkaraju, M.D., Ph.D., Stéphane BancelS. Gail Eckhardt, M.D., and Amir Nashat,Richard A. Young, Ph.D. Dr. SatoYoung chairs the nominating and corporate governance committee. Richard A. Young,Amir Nashat, Ph.D. served on the nominating and corporate governancethis committee from January tountil September 2016.2022. The nominating and corporate governance committee held one meetingfour meetings during fiscal 2016.2022.
Research and Development Committee
Our research and development committee’s responsibilities include:
Mr. Bancel, who will not stand for re-election, will also ceasereviewing our current and planned research and development, or R&D, programs and initiatives from a scientific perspective, providing feedback to be a member of our nominatingR&D management on those programs and corporate governance committee after this annual meeting. Upon the completion of the annual meeting,initiatives, and from time to time providing observations and strategic recommendations to our board of directors intendsdirectors;
serving as a sounding board for our R&D organization on R&D matters;
as requested, assisting management in identifying world-class experts to designate a third member toprovide strategic scientific and clinical advice regarding our nominatingprograms; and corporate governance committee.
identifying and discussing with the board significant emerging scientific and clinical issues and trends, as well as benchmarking our programs and R&D activities against our competitors.
The current members of our research and development committee are Srinivas Akkaraju, M.D., Ph.D., Deborah Dunsire, M.D., S. Gail Eckhardt, M.D., and Richard A. Young, Ph.D. Dr. Eckhardt chairs the research and development committee. Philip A. Sharp, Ph.D. served on this committee until September 2022. The research and development committee held three meetings during fiscal 2022.
Director Nomination Process
The process followed by our nominating and corporate governance committee to identify and evaluate director candidates includes requests to board members and others for recommendations, meetings from time to time to evaluate biographical information and background material relating to potential candidates and interviews of selected candidates by members of the nominating and corporate governance committee and our board of directors.
Criteria and Diversity
In considering whether to recommend to our board of directors any particularspecific candidate for inclusion in our board of directors’ slate of recommended director nominees, including candidates recommended by stockholders, the nominating and corporate governance committee of our board of directors applies the criteria set forth in our corporate governance guidelines. These criteria include the candidate’s integrity, business acumen, knowledge of our business and industry, the ability to act in the interests of all stockholders, and lack of conflicts of interest.
The director biographies on pages 8 to 1011 indicate each nominee’s experience, qualifications, attributes and skills that led our nominating and corporate governance committee and our board of directors to conclude he or she should continue to serve as a director. Our nominating and corporate governance committee and our board of directors believe that each of the nominees has the individual attributes and characteristics required of each of our directors, and the nominees as a group possess the skill sets and specific experience desired of our board of directors as a whole.
Our nominating and corporate governance committee does not have a policy (formal or informal) with respect to diversity, but believes that our board, taken as a whole, should embody a diverse set of skills, experiences and backgrounds. In this regard, the nominating and corporate governance committee also takes into consideration the diversity (for example, with respect to gender, race and national origin) of our board members. The nominating and corporate governance committee does not make any particular weighting of diversity or any other characteristic in evaluating nominees and directors.
Stockholder Nominations
Stockholders may recommend individuals to our nominating and corporate governance committee for consideration as potential director candidates by submitting their names, together with appropriate biographical information and background materials, and a statement as to whether the stockholder or groupnumber of stockholders making the recommendation has beneficially owned more than 5%shares of our common stock for at least a yearbeneficially owned by the stockholder making the recommendation, and certain other information as of the date such recommendation is made,set forth in our by-laws, to Syros Pharmaceuticals, Inc., Attention: Nominating and Corporate Governance Committee, 620 Memorial35 CambridgePark Drive, Suite 300,4th Floor, Cambridge, Massachusetts 02139. Assuming that02140. If appropriate biographical and background material has been provided on or before the dates set forth in this proxy statement under the heading “Other Matters – Stockholder Proposals for our 20182024 Annual Meeting”,Meeting,” the committee will evaluate stockholder-recommended
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candidates by following substantially the same process, and applying substantially the same criteria, as it follows for candidates submitted by others. If the board determines to nominate a stockholder-recommended candidate and recommends his or her election, then his or her name will be included in our proxy card for the next annual meeting.
Stockholders also have the right under our by-laws to directly nominate director candidates, without any action or recommendation on the part of the nominating and corporate governance committee or our board of directors, by following the procedures set forth under “Other Matters – Stockholder Proposals for our 20182024 Annual Meeting.”
Oversight of Risk
Our board of directors oversees our risk management processes directly and through its committees. Our management is responsible for risk management on a day-day basis. The role of our board of directors and its
committees is to oversee the risk management activities of management. Our board of directors fulfills this duty by discussing with management the policies and practices utilized by management in assessing and managing risks and providing input on those policies and practices. In general, our board of directors oversees risk management activities relating to business strategy, acquisitions, capital allocation, organizational structure and certain operational risks; our audit committee oversees risk management activities related to financial controls, and legal and compliance risks, and cybersecurity risks; our compensation committee oversees risk management activities relating to our compensation policies and practices;practices and management succession planning; and our nominating and corporate governance committee oversees risk management activities relating to the composition of our board of directors and management succession planning.corporate governance. Each committee reports to the full board of directors on a regular basis, including reports with respect to the committee’s risk oversight activities as appropriate. In addition, since risk issues often overlap, committees from time to timetime-to-time request that the full board of directors discuss particular risks.
Compensation Committee Interlocks and Insider Participation
None of our executive officers serves, or in the past has served, as a member of the board of directors or compensation committee, or other committee serving an equivalent function, of any entity that has one or more executive officers who serve as members of our board of directors or our compensation committee. None of the members of our compensation committee is, or ever has been, an officer or employee of our company.
Code of Business Conduct and Ethics
We have adopted a written code of business conduct and ethics that applies to our directors, officers and employees, including our principal executive officer and principal financial officer. A copy of the code is available on the “News“Investors & Investors—Corporate Media—Governance” section of our website, which is located at www.syros.com. Our board of directors is responsible for overseeing the code of business conduct and ethics and must approve any waivers of the code for directors, officers and employees. If we make any substantive amendments to, or grant any waivers from, the code of business conduct and ethics for any officer or director, we will disclose the nature of such amendment or waiver on our website or in a current report on Form 8-K.
Policies and Procedures for Related Person Transactions
Our board of directors has adopted a written related person transaction policy to set forth policies and procedures for the review of any transaction, arrangement or relationship in which our company is a participant, the amount involved exceeds the lesser of $120,000 or 1% of the average of our total assets at year-end for the last two completed fiscal years, and one of our executive officers, directors, director nominees or 5% stockholders, or their immediate family members, each of whom we refer to as a “related person,” has a direct or indirect material interest.
If a related person proposes to enter into such a transaction, arrangement or relationship, which we refer to as a “related party transaction,” the related person must report the proposed related person transaction to our principal financial officer. The policy calls for the proposed related person transaction to be reviewed and approved by our audit committee. Whenever practicable, the reporting, review and approval will occur prior to entry into the transaction. If advance review and approval is not practicable, the committee will review and, in its discretion, may ratify the related person transaction. The policy also permits the chair of the audit committee to review and, if deemed appropriate,
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approve proposed related person transactions that arise between committee meetings, subject to ratification by the committee at its next meeting. Any related person transactions that are ongoing in nature will be reviewed annually.
A related person transaction reviewed under this policy will be considered approved or ratified if it is authorized by the audit committee in accordance with the standards set forth in the policy after full disclosure of the related
person’s interests in the transaction. As appropriate for the circumstances, the policy provides that the audit committee will review and consider:
| the related person’s interest in the related person transaction; |
| the approximate dollar value of the amount involved in the related person transaction; |
| the approximate dollar value of the amount of the related person’s interest in the transaction without regard to the amount of any profit or loss; |
| whether the transaction was undertaken in the ordinary course of our business; |
| whether the terms of the transaction are no less favorable to us than the terms that could have been reached with an unrelated third party; |
| the purpose of, and the potential benefits to us of, the transaction; and |
| any other information regarding the related person transaction or the related person in the context of the proposed transaction that would be material to investors in light of the circumstances of the particular transaction. |
The audit committee may approve or ratify the related person transaction only if the audit committee determines that, under all of the circumstances, the transaction is in our best interests. The audit committee may impose any conditions on the related person transaction as it deems appropriate.
The policy also provides that transactions involving compensation of executive officers will be reviewed and approved by our compensation committee in the manner specified in its charter.
Related Person Transactions
In addition to the compensation arrangements with directors and executive officers described elsewhere in this proxy statement, since January 1, 2016,2021, we have engaged in the following transactions in which the amount involved exceeded the lesser of $120,000 or 1% of the average of our total assets at year-end for the last two completed fiscal years, and any of our executive officers, directors, director nominees or 5% stockholders, or their immediate family members, or any person who was in any of those categories at the time of such transaction, had a direct or indirect material interest. We believe that all of these transactions were on terms comparable to terms that could have been obtained from unrelated third parties.
Series B Preferred Stock Financing
Private Placement
In January 2016,On September 16, 2022, we issued andcompleted a private placement with several institutional investors, pursuant to which we sold an aggregate of 12,714,1506,387,173 shares of our Series B preferredcommon stock, and in lieu of shares of our common stock to certain investors, we sold such investors pre-funded warrants to purchase an aggregate of 7,426,739 shares of our common stock, and, in each case, accompanying warrants to purchase an aggregate of up to 13,813,912 additional shares of common stock (or pre-funded warrants to purchase common stock in lieu thereof) at a price of $9.40 per share of $3.1461,and accompanying warrant (or $9.399 per pre-funded warrant and accompanying warrant), for an aggregate purchase price of $40.0 million.approximately $129.9 million, before deducting estimated offering expenses payable by us and exclusive of any exercise of the warrants. The following table sets forthsummarizes the number of shares of our Series B preferred stock purchased by our directors, executive officers and 5% stockholders and their affiliates and
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the aggregate purchase price paid for such shares. Upon the closing of our IPO, all of the outstanding shares of our Series B preferred stock converted into shares of our common stock.
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| Shares of Series B |
| Aggregate | |
Name |
| Preferred Stock Purchased |
| Purchase Price | |
Entities affiliated with Deerfield Management |
| 6,357,077 |
| $ | 20,000,000 |
Entities affiliated with Fidelity |
| 1,589,269 |
| $ | 4,999,999 |
WuXi PharmaTech Healthcare Fund II, L.P. |
| 1,589,269 |
| $ | 4,999,999 |
Entities affiliated with Polaris |
| 1,271,415 |
| $ | 3,999,999 |
Total |
| 10,807,030 |
| $ | 33,999,997 |
Amir Nashat, Ph.D., a memberstock that members of our board of directors is a managing partner at Polaris. Jonathan Leff, who was a member of our board of directors at the time of this financing, is a partner of Deerfield Management. WuXi PharmaTech Healthcare Fund II, L.P., or Wuxi PharmaTech, was at the time of this financing a 5% stockholder.
IPO
In July 2016, we completed our IPO under which we issued and sold an aggregate of 4,600,000 shares of our common stock at a price per share of $12.50, for an aggregate purchase price of $57,500,000. The following table sets forth the number of shares of our common stock purchased by our directors, executive officers, and 5% stockholders andor their affiliates, and holders of more than 5% of our outstanding capital stock purchased in the aggregate purchase price paid for such shares.private placement.
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| Shares of Common Stock |
| Aggregate | |
Name |
| Purchased |
| Purchase Price | |
Entities affiliated with Fidelity |
| 1,000,000 |
| $ | 12,500,000 |
Entities affiliated with Deerfield Management |
| 400,000 |
| $ | 5,000,000 |
ARCH Venture Fund VII, L.P. |
| 400,000 |
| $ | 5,000,000 |
Entities affiliated with Flagship Ventures |
| 400,000 |
| $ | 5,000,000 |
Entities affiliated with Polaris |
| 400,000 |
| $ | 5,000,000 |
Total |
| 2,600,000 |
| $ | 32,500,000 |
Name of Stockholder | Shares of Syros Common Stock | Pre-Funded Warrants in Lieu of Shares of Common Stock | Accompanying Warrants | Total Purchase Price ($) | ||||||||||||
Flagship Pioneering Fund VIII, L.P. (1) | 700,000 | 1,420,000 | 2,120,000 | 19,926,580.00 | ||||||||||||
Invus Public Equities, L.P. | 1,063,829 | — | 1,063,829 | 9,999,992.60 | ||||||||||||
Ally Bridge MedAlpha Master Fund L.P. | 531,914 | — | 531,914 | 4,999,991.60 | ||||||||||||
Entities affiliated with Bain Capital Life Sciences, L.P. | 531,940 | 531,940 | 1,063,880 | 9,999,940.06 | ||||||||||||
Samsara BioCapital, L.P. (2) | 691,489 | — | 691,489 | 6,499,996.60 |
(1) | Douglas Cole, M.D., a general partner of Flagship Pioneering Fund VIII, L.P., or Flagship, is the spouse of Nancy Simonian, M.D., President, Chief Executive Officer and member of our board of directors. In connection with the private placement, Flagship had the right to designate a member of our board of directors. On September 16, 2022, Andrew M. Oh, a senior partner of Flagship, was elected to our board as the designee of Flagship following the closing of the private placement. |
(2) | Srinivas Akkaraju, M.D., Ph.D., a member of our board of directors, is one of the managers of Samsara BioCapital GP, LLC, which is the general partner of Samsara BioCapital, L.P., a venture capital firm. |
Consulting Agreement with Mr. Quirk
Gerald E. Quirk, Esq. has served as an executive officer of the company since October 2022, and before that, he served as an executive officer of the company from September 2016 to March 2022. Between March 2022 and September 2022, Mr. Quirk earned $370,142 pursuant to the terms of a general partnerconsulting agreement he entered into with our company that is unrelated to his service as an executive officer, which amount includes the fair value of Flagship Ventures, isa restricted stock unit award that vested during the spouse of Dr. Simonian.consulting period.
Investors’ Rights Agreement
We arePrior to its expiration in June 2021, we were a party to an amended and restated investors’ rights agreement, dated as of October 9, 2014, as amended, which we refer to as our investors’ rights agreement, with the purchasers of preferred stock prior to our IPO, including entities affiliated with Flagship Ventures, ARCH Venture Fund VII, L.P., entities affiliated with Fidelity,FMR LLC, entities affiliated with Deerfield Management,Flagship Ventures, entities affiliated with Polaris entities affiliated with WuXi PharmaTech,Partners (of which Amir Nashat is a managing partner), Nancy A. Simonian, M.D., and Phillip A. Sharp, Ph.D., and Stéphane Bancel. The investors’ rights agreement providesprovided these holders the right to demand that we file a registration statement or request that their shares be covered by a registration statement that we are otherwise filing.
Service Agreement with WuXi
Restrictions on the Hedging or Pledging of Our Securities
Our insider trading policy prohibits our employees and directors from purchasing financial instruments or otherwise engaging in transactions that hedge or offset, or are designed to hedge or offset, any decrease in the market value of any of our securities, including:
short sales and short sales “against the box”;
purchases or sales of puts, calls or other derivative securities; and
purchases of financial instruments (including prepaid variable forward contracts, equity swaps, collars and exchange funds).
These prohibitions also apply to family members living in the same household as our employees and directors, as well as entities influenced or controlled by our employees or directors.
Corporate Sustainability
Our mission is to build a sustainable company that provides long-term value for all our stakeholders. We support those environmental, social and governance (ESG) initiatives that may benefit the patients we aspire to serve, in a manner that aligns with our organizational culture, core values, and applicable regulatory requirements. Our board of directors provides oversight over these ESG initiatives by reference to those standards of the Sustainability Accounting Standards Boards relevant to our business as currently conducted. The specific activities reviewed by our board of directors with respect to fiscal 2022 included:
drug safety and side effects;
manufacturing and supply chain quality management;
business ethics, including anti-corruption and healthcare compliance matters;
employee recruitment, development and retention;
employee health and safety; and
energy, water and waste efficiency.
We are partycommitted to fostering an environment where all employees, regardless of race, sex, sexual orientation, gender identity, religion, ethnicity, national origin, physical disability, or age, are empowered to achieve their full potential. The unique talents, backgrounds and perspectives of each employee strengthens our coordinated expression, making our company stronger and helping us to achieve our mission of developing medicines to transform patients’ lives. Our Diversity, Equity & Inclusion (DEI) committee is an employee-led group that implements a service agreement with WuXi AppTec (Hong Kong) Limited, or WuXi, an affiliatevariety of grassroots initiatives including, among other things, transparent pay equity analyses, a DEI speaker series, and a company-wide allyship program. We are proud of the fact that women currently comprise roughly half of our prior 5% stockholder WuXi PharmaTech, under whichfunctional leaders and 40% of the members of our board of directors, and we engage WuXiremain committed to provide external researchcontinuing greater equity in the workplace and preclinical development services. We paid WuXi $1.3 million during fiscal 2016 for services provided under this agreement.expanding the representation of historically underrepresented individuals, recognizing that a diverse set of voices is vital to our success.
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EXECUTIVE AND DIRECTOR COMPENSATION
Executive Officers
Certain information regarding our executive officers who are not also directors, as of April 1, 2017,March 31, 2023 is set forth below.
Name | Age | Position(s) | ||||
| 62 | President & Chief Executive Officer | ||||
Conley Chee |
| 53 | Chief | |||
Jason Haas | 55 | Chief Financial Officer | ||||
Eric R. Olson, Ph.D. |
| 65 | Chief Scientific Officer | |||
Gerald E. Quirk, Esq. |
| 55 | Chief Legal Officer | |||
David A. Roth, M.D. |
| 60 | Chief Medical Officer | |||
Kristin Stephens | 50 | Chief Development Officer |
(1) | Please refer to page 11 for Dr. Simonian’s biography. |
Kyle D. Kuvalanka Conley Cheehas served asbeen our chief operatingcommercial officer since September 2015.2021. He previously served as global head of portfolio management, global pipeline strategy and precision medicine at Novartis Oncology, or Novartis, a global pharmaceutical company from October 2018 to February 2021. In this role, Mr. Chee had strategic responsibility for shaping Novartis’ overall pipeline, including driving commercial planning for the company’s early-stage portfolio and diagnostics strategy for oncology. Earlier in his career at Novartis, Mr. Chee served as vice president – global head oncology lung franchise from 2015 to October 2018, as well as in multiple U.S. sales and marketing leadership roles. Prior to joining Syros,Novartis, Mr. KuvalankaChee spent five years in roles of increasing responsibility at Pfizer, Inc., a global pharmaceutical company, ultimately serving as team leader of international business development. He holds a B.Sc. Pharm from the University of Alberta and an M.B.A. from the Richard Ivey School of Business at the University of Western Ontario and completed his residency in Clinical Pharmacy at the University of British Columbia.
Jason Haas has been our chief financial officer since October 2021. He previously served as chief business officer and principal financial and accounting officerco-head of Blueprint Medicines Corporation,Americas, healthcare investment banking at Barclays from June 2016 to October 2021. Previously, he served as head of Americas, healthcare investment banking at Deutsche Bank from 2012 to June 2016. Prior to his role at Deutsche Bank, he was a biopharmaceutical company, from September 2013 to September 2015. From 2002 to September 2013,managing director on the healthcare investment banking team at Goldman Sachs & Co. Mr. Kuvalanka worked at Takeda Pharmaceutical Company and at MillenniumHaas currently serves on the board of directors of Ligand Pharmaceuticals Inc. prior to its acquisition by Takeda, including as vice president, corporate strategy, business development and alliance management from 2009 to September 2013.Incorporated, a public biotechnology company. Mr. KuvalankaHaas holds a B.A. in International Relations and Economics from WesleyanColgate University and an M.B.A. in Finance from The WhartonColumbia Business School of the University of Pennsylvania.School.
Eric R. Olson, Ph.D. has been our chief scientific officer since April 2013. He previously served as research vice president for respiratory diseases at Vertex Pharmaceuticals, Inc., a biotechnology company, from 2001 to May 2013. Dr. Olson has also held positions as the director of antibacterials and molecular sciences departments at Warner-Lambert Co. as well as a research scientist focused on gene expression systems with The Upjohn Company, both of which were acquired by Pfizer Inc., a pharmaceutical company.company, or Pfizer. Dr. Olson serves on the boards of the Cystic Fibrosis Foundation and the National Brain Tumor Society. Dr. Olson received a B.S. in microbiology and immunology from the University of Minnesota and a Ph.D. in microbiology and immunology from the University of Michigan.
Gerald E. Quirk, Esq. has served as our chief legal officer since October 2022, and previously served as a senior advisor to Syros from March 2022 to September 2016.2022, as our chief operations officer from June 2021 to March 2022, as our chief legal and administrative officer from June 2017 to June 2021, and as our chief legal officer from September 2016 to June 2017. He previously served as executive vice president, business operations and general counsel of Tokai Pharmaceuticals, Inc., a biotechnologybiopharmaceutical company, from May 2015 to August 2016. Prior to that, Mr. Quirk was a partner and co-chair of the life sciences practice at Choate, Hall & Stewart
LLP, a Boston law firm, from August 2012 until May 2015. Mr. Quirk previously served as vice president, corporate affairs and general counsel at Infinity Pharmaceuticals, Inc. with responsibility for the company’s legal, intellectual property, finance and corporate communications activities,, a pharmaceutical company, or Infinity, from August 2006 until August 2012, and prior to that held legal and business development positions of increasing responsibility at Genzyme Corporation.Genzyme. Mr. Quirk holds a B.A. in political science from Swarthmore College, an Ed.M. in educational administration from Harvard University, and a J.D. from Northeastern University.
David A. Roth, M.D. has been our chief medical officer since December 2015. Previously, Dr. Roth was employed by Infinity Pharmaceuticals, Inc., a pharmaceutical company, from September 2013 until September 2015, serving most recently as its executive vice president and chief medical officer and previously as its senior vice president of clinical development and medical affairs. Prior to joining Infinity, Dr. Roth was the vice president, early development in the oncology business unit of Pfizer Inc., a pharmaceutical company, from 2009 to August 2013. Prior to joining the pharmaceutical industry, Dr. Roth’s experience included over 10ten years in research and clinical practice as an academic hematologist, and he served on the full-time faculty at Harvard Medical School and Beth Israel Deaconess Medical Center in Boston. Dr. Roth currently serves on the board of directors of Allarity Therapeutics, Inc., a public biopharmaceutical company. Dr. Roth received his B.S. from the Massachusetts Institute of TechnologyMIT and his M.D. from Harvard Medical School in the Harvard MIT Division of Health Sciences and Technology, where he remains on the affiliated faculty.Technology.
Kristin Stephens has been our chief development officer since June 2020. She previously served as our senior vice president of product development from August 2018 to June 2020, vice president of development operations from March 2018 to August 2018, and vice president of clinical operations from October 2015 to March 2018. Prior to Syros, Ms. Stephens spent nearly ten years at Millennium and Takeda in a variety of roles with escalating responsibilities, serving most recently as vice president of global clinical operations. Earlier in her career, Ms. Stephens worked at Quintiles Strategic Research Services, Clinical Assistance Programs and Eastern Cooperative Oncology Group. Ms. Stephens earned her B.A. in mathematics and psychology at William Smith College.
This section discusses the material elements of our executive compensation policies for our “named executive officers” and the most important factors relevant to an analysis of these policies. For 2016,2022, our “namednamed executive officers”officers are Nancy A. Simonian, M.D., our President and Chief Executive Officer, and our three other most highly compensated
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executive officers, Kyle D. Kuvalanka, our Chief Operating Officer, Gerald E. Quirk, Esq., our Chief Legal Officer, and David A. Roth, M.D., our Chief Medical Officer, and Eric R. Olson, Ph.D., our Chief Scientific Officer. In addition, this section provides qualitative information regarding the manner and context in which compensation is awarded to and earned by our named executive officers and is intended to place in perspective the data presented in the following tables and the corresponding narrative.
Summary Compensation Table
The following table sets forth information regarding compensation earned by our named executive officers during the years indicated.
Name and Position of Named Executive | Year | Salary ($) | Stock Awards ($)(1) | Option Awards ($)(1) | Non-Equity Incentive Plan Compensation ($)(2) | All Other Compensation ($)(3) | Total ($) | |||||||||||||||||||||
Nancy A. Simonian, M.D. (4) | 2022 | 636,615 | 1,557,683 | 974,802 | 316,800 | 1,980 | 3,487,880 | |||||||||||||||||||||
President & Chief Executive Officer | 2021 | 615,923 | — | 2,413,212 | 322,905 | 576 | 3,352,617 | |||||||||||||||||||||
David A. Roth, M.D. | 2022 | 497,538 | 699,258 | 380,317 | 180,000 | 1,980 | 1,759,093 | |||||||||||||||||||||
Chief Medical Officer | 2021 | 482,385 | — | 944,646 | 185,158 | 576 | 1,612,765 | |||||||||||||||||||||
Eric R. Olson, Ph.D. | 2022 | 487,385 | 674,020 | 327,054 | 176,400 | 3,810 | 1,668,669 | |||||||||||||||||||||
Chief Scientific Officer | 2021 | 481,115 | — | 746,191 | 180,686 | 576 | 1,408,568 |
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| Non-Equity |
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| Incentive Plan |
| Option |
| All Other |
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| Salary |
| Bonus |
| Compensation |
| Awards |
| Compensation |
| Total |
Name and Principal Position |
| Year |
| ($) |
| ($) |
| ($) |
| ($)(1) |
| ($)(2) |
| ($) |
Nancy Simonian, M.D.(3) |
| 2016 |
| 473,260 |
| — |
| 212,500 |
| 1,248,816 |
| 270 |
| 1,934,846 |
President & Chief Executive Officer |
| 2015 |
| 425,000 |
| — |
| — |
| 723,248 |
| 270 |
| 1,148,518 |
Kyle D. Kuvalanka(4) |
| 2016 |
| 380,000 |
| — |
| 115,045 |
| — |
| 270 |
| 495,315 |
Chief Operating Officer |
| 2015 |
| 106,692 |
| 122,500 |
| — |
| 1,262,638 |
| 68 |
| 1,491,898 |
Gerald E. Quirk, Esq. (5) |
| 2016 |
| 98,269 |
| — |
| 28,731 |
| 1,333,124 |
| 68 |
| 1,460,192 |
Chief Legal Officer |
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David A. Roth, M.D.(6) |
| 2016 |
| 380,000 |
| — |
| 115,045 |
| — |
| 270 |
| 495,315 |
Chief Medical Officer |
| 2015 |
| 26,064 |
| — |
| — |
| 1,437,272 |
| — |
| 1,463,336 |
(1) | The amounts reported in the “Stock Awards” and “Option Awards” |
(2) |
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(3) | The amounts reported in the “All Other Compensation” column reflect, for each named executive officer, the cost to us of life insurance premiums paid for the named executive officer. |
| (4) | Dr. Simonian also serves as a member of our board of directors but does not receive any additional compensation for her service as a director. |
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Narrative Disclosure to Summary Compensation Table
We review compensation for our executive officers annually. The material terms of the elements of our executive compensation program for 20162022 are described below.
Our compensation committee sets base salaries and bonuses and grants equity incentive awards to our executive officers. In setting base salaries and bonuses and granting equity incentive awards,bonus targets, our compensation committee considers compensation for comparable positions in the market, the historical compensation levels of our executives, individual and corporate performance as compared to our expectations and objectives,objectives. In evaluating and granting equity incentive awards, our compensation committee considers the value of equity awards granted for comparable positions in the market, our desire to motivate our employees to achieve short- and long-term results that are in the best interests of our stockholders, andour desire to foster a long-term commitment to our company.company, as well as the dilutive impact of equity incentive awards to stockholders and capacity limitations under our stock incentive plan. As part of this process, Dr. Simonian, as our president and chief executive officer, prepares performance evaluations for the other executive officers and recommends annual salary increases, annual stock optionequity awards and
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cash bonuses to the compensation committee. The compensation committee conducts a performance evaluation of Dr. Simonian. The compensation committee consults with the board of directors as to the achievement of corporate objectives that drive contingent compensation awards.
During its annual compensation review, our compensation committee also consults with external advisors. In fiscal 2016,2022, the compensation committee engaged Compensia Inc. as its independent compensation consultant to provide comparative data on executive compensation practices in our industry and assess our executives’ compensation relative to comparable companies.
Base Salary
We use base salaries to recognize the experience, skills, knowledge and responsibilities required of all our employees, including our named executive officers. None of our named executive officers is currently party to an employment agreement or other agreement or arrangement that provides for automatic or scheduled increases in base salary.
In 2015, we paid a base salaryFebruary 2021, the compensation committee of $425,000 to Dr. Simonian. In January 2016,our board of directors set Dr. Simonian’s base salary was increased to $455,000 and in September 2016, her annual base salary was further increased to $500,000 retroactive to the closing of our IPO in July 2016. Dr. Simonian’s base salary increased to $516,000 effective February 16, 2017.
Mr. Kuvalanka commenced employment with us in September 2015. In 2015, we paid him a base salary of $106,692 for his partial year of employment, and his annualized base salary was $380,000.at $618,000 effective February 22, 2021. In February 2022, the compensation committee increased Dr. Roth commenced employment with us in December 2015. In 2015, we paid him a base salary of $26,064 for his partial year of employment, and hisSimonian’s annualized base salary was $380,000. Base salaries for Mr. Kuvalanka and Dr. Roth did not increase in fiscal 2016, but were increased to $392,000 for both officers$640,000 effective February 16, 2017. Mr. Quirk commenced employment with us in September 2016.21, 2022. In 2016, we paid him a base salary of $98,269 for his partial year of employment, and hisFebruary 2023, the compensation committee increased Dr. Simonian’s annualized base salary was $365,000. Mr. Quirk’sto $666,000 effective March 6, 2023.
In February 2021, the compensation committee of our board of directors set Dr. Roth’s annualized base salary was not adjusted for 2017.at $484,000 effective February 22, 2021. In February 2022, the compensation committee increased Dr. Roth’s annualized base salary to $500,000 effective February 21, 2022. In February 2023, the compensation committee increased Dr. Roth’s annualized base salary to $520,000 effective March 6, 2023.
In February 2021, the compensation committee of our board of directors set Dr. Olson’s annualized base salary at $473,000 effective February 22, 2021. In February 2022, the compensation committee increased Dr. Olson’s annualized base salary to $490,000 effective February 21, 2022. In February 2023, the compensation committee increased Dr. Olson’s annualized base salary to $509,600 effective March 6, 2023.
Cash Incentives
During 2016, weWe have established a framework under which the compensation committee would, in its discretion, award annual performance-based cash bonuses to our executive officers for up to a specific percentage of his or her salary as a vehicle to reward achievement of value driving milestones and recognize individual performance. Dr. Simonian iswas eligible for a performance-based cash bonus of up to 50%a percentage of her annual base salary, subject to achievement of corporate goals as determined by the compensation committee. Her bonus target was 55% of her annual base salary in the year ended December 31, 2021, or fiscal 2021, and fiscal 2022. Our other named executive officers are eligible for a performance-based cash bonus of up to 35%a percentage of such named executive officer’s base salary, 90% of which is tied to achievement of corporate goals as determined by the compensation committee, and 10% of which is tied to the achievement of individual goals as recommended by Dr. Simonian and approved by the compensation committee. The bonus target for our other named executive officers was 40% of the applicable officer’s annual base salary for both fiscal 2021 and fiscal 2022.
In February 2017,2022, we made cash bonus awards of $212,500$322,905 to Dr. Simonian, $115,045$185,158 to each of Mr. Kuvalanka and Dr. Roth and $28,731$180,686 to Mr. Quirk,Dr. Olson based on the compensation committee’s assessment of achievement of corporate and individual goals during fiscal 2021. In February 2023, we made cash bonus awards of $316,800 to Dr. Simonian, $180,000 to Dr. Roth and in$176,400 to Dr. Olson based on the casecompensation committee’s assessment of Mr. Quirk, the percentageachievement of the year in which he was employed by Syros.corporate and individual goals during fiscal 2022.
In 2015, we paid a sign‑on bonus of $122,500 to Mr. Kuvalanka upon his commencement of employment with Syros.
Equity Incentives
Although we do not have a formal policy with respect to the grant of equity incentive awards to our executive officers, or any formal equityshare ownership policy or guidelines applicable to them, we believe that equity grantsawards are very effective in supporting executive recruitment, motivation, and retention in a highly competitive marketplace for experienced talent, provide our executivesexecutive officers with a strong link to our long‑termlong-term performance, create an ownership culture, and help to align the interests of our executivesexecutive officers and our stockholders. In addition, weWe believe that equity grantsawards with a time‑basedtime-based vesting featurecondition promote executive retention because this feature incents our executive officers to remain in our employment during the award’s vesting period, andperiod. At the same time, we believe that equity grantsawards with a performance‑based feature incents ourperformance-based vesting aligns executive officers to focus on whatcompensation with the achievement of milestones that we see as key business goals.believe will drive stockholder return. Accordingly, the compensation committee periodically reviews the equity incentive compensation holdings of our named executive officers and from time to time may grant equity incentive awards to them in the form of stock options.
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In 2015, we madethe equity incentive awards that it grants in order to ensure the long-term sustainability of our equity incentive plan. As a result of the ongoing volatility in the equity markets for development-stage companies in our industry and the imperative to continue to motivate and retain our executive officers including Dr. Simonian, Mr. Kuvalanka and Dr. Roth.through the completion of the potential value-creating clinical milestones in the future, we expect higher levels of dilution from equity incentive awards in 2023 than in prior years.
In February 2021, Dr. Simonian was granted three optionsan option to purchase up to 100,368, up to 43,048 and up to 43,04730,400 shares of our common stock, respectively. The firstDr. Roth was granted an option to purchase 11,900 shares of our common stock, and second grantsDr. Olson was granted an option to
purchase 9,400 shares of our common stock. These options vested as to 25% of the shares on February 5, 2016 and June 9, 2016, respectively,28, 2022, with the remaining shares vesting in equal monthly installments thereafter through February 5, 2019 and June 9, 2019, respectively. Dr. Simonian’s third grant vests upon28, 2025, subject to the achievement of performance‑based criteria, with 50% ofapplicable officer’s continued service through the shares having vested upon the closing of our IPO in July 2016 and the remaining 50% of the sharesapplicable vesting upon the earlier to occur of clinical proof‑of‑concept studies for a company drug candidate and a significant development or partnership deal, in each case as determined by our board of directors, and in any event will vest in full on June 9, 2021.
date.
In March 2016,February 2022, Dr. Simonian was granted an option to purchase up to 93,33337,500 shares of our common stock, whichDr. Roth was granted an option to purchase 12,500 shares of our common stock, and Dr. Olson was granted an option to purchase 10,000 shares of our common stock. These options vested as to 25% of the shares on March 31, 2017,February 28, 2023, with the remaining shares vesting in equal monthly installments thereafter through February 28, 2026, subject to the applicable officer’s continued service through the applicable vesting date. In addition, Dr. Simonian was granted a restricted stock unit award with respect to 24,000 shares of our common stock and Drs. Roth and Olson were each granted a restricted stock unit award with respect to 8,000 shares of our common stock. These restricted stock units vested as to 25% of the shares on March 31, 2020. 2023, with the remaining shares vesting in equal annual installments through March 31, 2026, subject to the applicable officer’s continued service through the applicable vesting date. Dr. Simonian was also granted a restricted stock unit award with respect to 40,000 shares of our common stock and Drs. Roth and Olson were each granted a restricted stock unit award with respect to 20,000 shares of our common stock. These restricted stock units will vest in full on March 31, 2025, subject to the applicable officer’s continued service through the applicable vesting date.
In September 2016,October 2022, Dr. Simonian was granted an option to purchase an additional 75,000115,000 shares of our common stock, whichDr. Roth was granted an option to purchase 49,750 shares of our common stock, and Dr. Olson was granted an option to purchase 44,500 shares of our common stock. These options will vest as to 25%50% of the shares on September 16, 2017, with the remaining shares vesting in equal monthly installments thereafter through September 16, 2020.
In September 2015, Mr. Kuvalanka was granted two options to purchase up to 189,252October 31, 2023, and up to 68,819 shares of common stock, respectively. The first grant vested as to 25%50% of the shares on September 21, 2016,October 31, 2024, subject to the applicable officer’s continued service through the applicable vesting date. In addition, Dr. Simonian was granted a restricted stock unit award with the remainingrespect to 80,250 shares vesting in equal monthly installments thereafter through September 21, 2019. Mr. Kuvalanka’s second grant vests upon the achievement of performance‑based criteria, with 40% of the shares having vested upon the closing of our IPO in July 2016, 40% vesting upon the execution by us of a collaboration agreement and 20% of the shares vesting upon clinical proof‑of‑concept for a company drug candidate, in each case as determined by our board of directors, and in any event will vest in full on September 21, 2021. Mr. Kuvalanka was not granted anycommon stock, options during 2016.
In December 2015, Dr. Roth was granted two optionsa restricted stock unit award with respect to purchase up to 172,047 and up to 51,61437,750 shares of our common stock, respectively. The first grant vestedand Dr. Olson was granted a restricted stock unit award with respect to 34,000 shares of our common stock. These restricted stock units will vest as to 25%50% of the shares on December 7, 2016, with the remaining shares vesting in equal monthly installments thereafter through December 7, 2019. Dr. Roth’s second grant vests upon the achievement of performance‑based criteria, with 75% of the shares vesting upon clinical proof‑of‑concept for a company drug candidateOctober 31, 2023, and 25% of the shares vesting upon execution by us of a collaboration agreement, in each case as determined by our board of directors, and in any event will vest in full on December 7, 2021. Dr. Roth was not granted any stock options during 2016.
In September 2016, Mr. Quirk was granted two options to purchase up to 105,000 and up to 35,000 shares of common stock, respectively. The first grant will vest as to 25%50% of the shares on September 26, 2017, withOctober 31, 2024, subject to the remaining sharesapplicable officer’s continued service through the applicable vesting in equal monthly installments thereafter through September 26, 2020. Mr. Quirk’s second grant vests upon the achievement of performance-based criteria, with 67% of the shares vesting upon execution by us of a collaboration agreement, and 33% of the shares vesting upon the earlier of clinical proof-of-concept for a company drug candidate other than SY-1425 or initiation of the first pivotal trial of a company drug candidate, in each case as determined by our board of directors, and in any event will vest in full on September 26, 2022.date.
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Outstanding Equity Awards at Fiscal Year End 2016
2022
The following table sets forth information regarding outstanding equity awards which consist entirely of stock options, held by our named executive officers as of December 31, 2016.2022.
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| Number of Securities |
| Number of Securities |
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| Underlying |
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| Unexercised |
| Unexercised |
| Option |
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| Options |
| Options |
| Exercise |
| Option |
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| Exercisable |
| Unexercisable |
| Price |
| Expiration |
Name |
| (#) |
| (#) |
| ($/share) |
| Date |
Nancy Simonian, M.D. |
| 23,455 |
| — |
| 1.01 |
| 5/21/2023 |
|
| — |
| 75,050 | (1) | 1.01 |
| 5/21/2023 |
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| 3,334 | (2) | 8,750 | (2) | 3.04 |
| 10/21/2024 |
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| 16,729 | (3) | 54,366 | (3) | 3.04 |
| 2/4/2025 |
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| 16,143 | (4) | 26,905 | (4) | 3.04 |
| 6/8/2025 |
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| 21,523 | (5) | 21,524 | (5) | 3.04 |
| 6/8/2025 |
|
| — |
| 93,333 | (6) | 8.51 |
| 3/30/2026 |
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| — |
| 75,000 | (7) | 12.17 |
| 9/15/2026 |
Kyle D. Kuvalanka |
| 59,141 | (8) | 130,111 | (8) | 6.94 |
| 9/20/2025 |
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| 27,528 | (9) | 41,291 | (9) | 6.94 |
| 9/20/2025 |
Gerald E. Quirk, Esq. |
| — |
| 105,000 | (10) | 13.30 |
| 9/26/2026 |
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| — |
| 35,000 | (11) | 13.30 |
| 9/26/2036 |
David A. Roth, M.D. |
| 43,011 | (12) | 129,036 | (12) | 9.08 |
| 12/22/2025 |
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| — |
| 51,614 | (13) | 9.08 |
| 12/22/2025 |
Option Awards | Stock Awards | |||||||||||||||||||||||
Current Named Executive Officers | Number of Securities Underlying Unexercised Options Exercisable (#) | Number of Securities Underlying Unexercised Options Unexercisable (#) | Option Exercise Price ($/ share) | Option Expiration Date | Number of Shares or Units of Stock That Have Not Vested (#) | Market Value of Shares or Units of Stock That Have Not Vested ($)(1) | ||||||||||||||||||
Nancy A. Simonian, M.D. | 3,766 | (2) | — | 30.40 | 2/4/2025 | 24,000 | (8) | 86,160 | ||||||||||||||||
3,483 | (2) | — | 30.40 | 6/8/2025 | 40,000 | (9) | 143,600 | |||||||||||||||||
2,152 | (2) | — | 30.40 | 6/8/2025 | 80,250 | (10) | 288,098 | |||||||||||||||||
7,916 | (2) | — | 85.13 | 3/30/2026 | ||||||||||||||||||||
7,499 | (2) | — | 121.70 | 9/15/2026 | ||||||||||||||||||||
17,500 | (2) | — | 109.00 | 2/9/2027 | ||||||||||||||||||||
28,001 | (2) | — | 109.00 | 2/15/2028 | ||||||||||||||||||||
27,312 | (3) | 1,188 | (3) | 67.10 | 2/11/2029 | |||||||||||||||||||
20,824 | (4) | 8,575 | (4) | 75.40 | 2/12/2030 | |||||||||||||||||||
13,932 | (5) | 16,467 | (5) | 114.10 | 2/16/2031 | |||||||||||||||||||
— | (6) | 37,499 | (6) | 15.90 | 2/14/2032 | |||||||||||||||||||
— | (7) | 115,000 | (7) | 6.73 | 10/4/2032 | |||||||||||||||||||
David A. Roth, M.D. | 22,364 | (2) | — | 90.80 | 12/22/2025 | 8,000 | (8) | 28,720 | ||||||||||||||||
6,349 | (2) | — | 109.00 | 2/9/2027 | 20,000 | (9) | 71,800 | |||||||||||||||||
7,499 | (2) | — | 109.00 | 2/15/2028 | 37,750 | (10) | 135,523 | |||||||||||||||||
7,187 | (3) | 312 | (3) | 67.10 | 2/11/2029 | |||||||||||||||||||
6,657 | (4) | 2,742 | (4) | 75.40 | 2/12/3030 | |||||||||||||||||||
5,453 | (5) | 6,446 | (5) | 114.10 | 2/16/2031 | |||||||||||||||||||
— | (6) | 12,499 | (6) | 15.90 | 2/14/2032 | |||||||||||||||||||
— | (7) | 49,750 | (7) | 6.73 | 10/4/2032 | |||||||||||||||||||
Eric R. Olson, Ph.D. | 11,569 | (2) | — | 10.10 | 5/21/2023 | 8,000 | (8) | 28,720 | ||||||||||||||||
453 | (2) | — | 13.88 | 9/3/2024 | 20,000 | (9) | 71,800 | |||||||||||||||||
3,477 | (2) | — | 30.38 | 2/4/2025 | 34,000 | (10) | 122,060 | |||||||||||||||||
2,584 | (2) | — | 30.40 | 2/4/2025 | ||||||||||||||||||||
6,349 | (2) | — | 109.00 | 2/9/2027 | ||||||||||||||||||||
7,499 | (2) | — | 109.00 | 2/15/2028 | ||||||||||||||||||||
7,187 | (3) | 313 | (3) | 67.10 | 2/11/2029 | |||||||||||||||||||
6,657 | (4) | 2,743 | (4) | 75.40 | 2/12/3030 | |||||||||||||||||||
4,302 | (5) | 5,092 | (5) | 114.10 | 2/16/2031 | |||||||||||||||||||
— | (6) | 9,999 | (6) | 15.90 | 2/14/2032 | |||||||||||||||||||
— | (7) | 44,500 | (7) | 6.73 | 10/4/2032 |
(1) |
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(2) | This option |
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(3) | This option was granted on February |
(4) | This option was granted on |
(5) | This option was granted on |
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| (6) | This option was granted on |
| (7) | This option was granted on |
| (8) | This |
(9) | This restricted stock unit award will vest in full on |
(10) | This |
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Employment andAgreements; Potential Payments upon Termination or Change in Control Arrangements
We have entered into written offer letters with each of our named executive officers. These agreementsoffer letters set forth the terms of the named executive officer’s compensation, including his or her initial base salary, severance and annual cash bonus opportunity. In addition, the agreementsoffer letters provide that the named executive officers are eligible to participate in company‑sponsoredcompany-sponsored benefit programs that are available generally to all of our employees. In connection with the commencement of their employment with us, our named executive officers executed our standard invention and non‑disclosurenon-disclosure agreement and non‑competitionnon-competition and non‑solicitationnon-solicitation agreement.
Change in Control
The offer letter with Dr. Simonian provides that if her employment is terminated by us without cause, or by her with good reason, as such terms are defined in her offer letter, she will receive monthly severance payments equal to her then‑currentthen-current monthly rate of salary rate for 12 months and payment of an incentive bonus pro‑ratedprorated for the portion of the then‑currentthen-current calendar year during which she was employed by us, subject to certain conditions, including the execution of a release of all claims against the Company. In addition, inif within the event ofthree months prior to a change in control of our company, as definedor in the offer letter, all unvested stock options then held by Dr. Simonian will vest in full 12twelve months after thefollowing a change in control, or earlier if herthe employment of Dr. Simonian is terminated by us without cause or by her forwith good reason, subject to certain conditions, we will (i) extend the severance benefits of Dr. Simonian for an additional six months, such that the total severance benefit period shall be 18 months, (ii) in contemplationlieu of pursuantthe incentive bonus described above, pay to or followingDr. Simonian a changelump sum amount equal to 150% of her target bonus in control, referred toeffect for the fiscal year in which her separation from employment occurs and (iii) accelerate the vesting of all unvested stock options held by her as of the CIC Equity Vesting.
date her employment is terminated such that 100% of such options shall become fully vested and exercisable effective as of such date.
The offer letter with each of Messrs. Kuvalanka and Quirk and Dr. Rothour other named executive officers provides that if his employment is terminated by us without cause, or by him with good reason, as such terms are defined in his offer letter, he will receive monthly severance payments equal to his then‑currentthen-current monthly rate of salary for nine months, subject to certain conditions, including the execution of a release of all claims against the Company. Messrs. Kuvalanka and Quirk and Dr. Roth are also eligibleIn addition, if within the three months prior to a change in control or in the twelve months following a change in control, the employment of such named executive officer is terminated by us without cause or by him with good reason, subject to certain conditions, we will (i) extend the severance benefits of such named executive officer for an additional three months, such that the total severance benefit period shall be one year, (ii) pay to such named executive officer a lump sum amount equal to his target bonus in effect for the CIC Equity Vesting.fiscal year in which his separation from employment occurs and (iii) accelerate the vesting of all unvested stock options held by him as of the date his employment is terminated such that 100% of such options shall become fully vested and exercisable effective as of such date.
Other Agreements
We have also entered into employee confidentiality, inventions, non-solicitation, and non-competition agreements with each of our named executive officers. Under the employee confidentiality, inventions, non-solicitation, and non-competition agreements, each named executive officer has agreed (1) not to compete with us during his or her employment and for a period of one year after the termination or cessation of his or her employment for any reason, (2) not to solicit our employees during his or her employment and for a period of one year after the termination or cessation of his or her employment for any reason, (3) to protect our confidential and proprietary information and (4) to assign to us related intellectual property developed during the course of his or her employment.
401(k) Retirement Plan
We maintain a 401(k) retirement plan that is intended to be a tax-qualified defined contribution plan under Section 401(k) of the Internal Revenue Code. In general, all of our employees are eligible to participate, beginning on the first day of the month following commencement of their employment. The 401(k) plan includes a salary deferral arrangement pursuant to which participants may elect to reduce their current compensation by up to the statutorily prescribed limit, equal to $18,000$20,500 in 2016,2022 and $19,500 in 2021, and have the amount of the reduction contributed to the 401(k) plan. Participants over the age of 50 are entitled to an additional catch-up contribution up to the statutorily prescribed limit, equal to $6,000$6,500 in 2016. Effective January 1, 2017, we determined toeach of 2022 and 2021. We make matching contributions at a rate of 100% of each employee’s contribution up to a maximum matching contribution of 1%2% of the employee’s compensation and 50% of each employee’s contribution in excess of 1%2% up to a maximum of 6% of the employee’s compensation.
Indemnification
For a summary of certain indemnification agreements with our named executive officers, see “Limitation of Liability and Indemnification” below.
Section 162(m) of the Internal Revenue Code of 1986, as amended, or the Code, generally disallows a tax deduction to public companies for compensation in excess of $1 million paid in any taxable year to each of certain of the company’s current and former executive officers. Historically, compensation that qualified under Section 162(m) as performance-based compensation was exempt from the deduction limitation. However, subject to certain transition rules, the tax reform legislation signed into law on December 22, 2017 eliminated the qualified performance-based compensation exception. As a result, for taxable years beginning after December 31, 2017, all compensation in excess of $1 million paid in any taxable year to each of the specified officers that is not covered by the transition rules will not be deductible by us. The Compensation Committee has and will continue to review on a periodic basis the potential effect of Section 162(m) and may use its judgment to authorize compensation payments that may be in excess of the limit when it believes such payments are appropriate and in the best interests of our company and our stockholders.
PAY VERSUS PERFORMANCE
The following tables and related disclosures provide information about (i) the “total compensation” of our principal executive officer, or the PEO, and our other named executive officers, or the Other NEOs, as presented in the Summary Compensation Table on page 22, or the SCT Amounts, (ii) the “compensation actually paid” to our PEO and our Other NEOs, as calculated pursuant to the SEC’s pay-versus-performance rules, or the CAP Amounts, (iii) certain financial performance measures, and (iv) the relationship of the CAP Amounts to those financial performance measures.
This disclosure has been prepared in accordance with Item 402(v) of Regulation S-K under the Exchange Act and does not necessarily reflect value actually realized by the executives or how our Compensation Committee evaluates compensation decisions in light of company or individual performance.
Year (1) | Summary Compensation Table Total for PEO ($) | Compensation Actually Paid to PEO(2) ($) | Average Summary Compensation Table Total for Non-PEO Named Executive Officers ($) | Average Compensation Actually Paid to Non-PEO Named Executive Officers(2) ($) | Value of Initial Fixed $100 Investment Based On Total Shareholder Return ($) | Net Income (Loss) ($) | ||||||||||||||||||
2022 | 3,487,880 | 746,824 | 1,713,881 | (443,748 | ) | 3.31 | (94,654,000 | ) | ||||||||||||||||
2021 | 3,352,617 | (2,760,336 | ) | 2,053,952 | 508,804 | 30.05 | (86,558,000 | ) |
(1) | Our PEO was Nancy A. Simonian, M.D., in both 2022 and 2021. Our Other NEOs were David A. Roth, M.D. (both 2022 and 2021), Eric R. Olson, Ph.D. (2022) and Jason Haas (2021). |
(2) | The following table describes the adjustments, each of which is prescribed by SEC rule, to calculate the CAP Amounts from the SCT Amounts. The SCT Amounts and the CAP Amounts do not reflect the actual amount of compensation earned or received by or paid to our named executive officers during the applicable years, but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act. |
Adjustments | 2022 | 2021 | ||||||||||||||
PEO | Other NEOs* | PEO | Other NEOs* | |||||||||||||
SCT Amounts | 3,487,880 | 1,713,881 | 3,352,617 | 2,053,952 | ||||||||||||
(Subtract): Aggregate grant date fair value for stock awards and option awards included in SCT Amounts for the covered fiscal year | (2,532,484 | ) | (2,080,649 | ) | (2,413,213 | ) | (1,652,898 | ) | ||||||||
Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end | 878,672 | 737,266 | 394,968 | 831,463 | ||||||||||||
Add (Subtract): Year-over-year change in fair value (from the end of the prior fiscal year) at covered fiscal year end of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end | (349,884 | ) | (234,356 | ) | (3,051,399 | ) | (572,152 | ) | ||||||||
Add (Subtract): Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year | (737,360 | ) | (579,890 | ) | (1,043,309 | ) | (151,561 | ) | ||||||||
CAP Amounts (as calculated) | 746,824 | (443,748 | ) | (2,760,336 | ) | 508,804 |
* | Amounts presented are averages for the entire group of Other NEOs in each respective year. |
For the equity values included in the above tables, the valuation assumptions used to calculate fair values of stock options were materially different from those disclosed at the time of the grant of the stock options. The assumptions used in determining fair value of the stock options that vested during 2021 and 2022, or that were outstanding as of December 31, 2021 or December 31, 2022, as applicable, are as follows:
Options Vested During Year or Outstanding on December 31 of: | ||||
2022 | 2021 | |||
Expected Volatility | 79.95%-90.99% | 79.95%-92.5% | ||
Risk-Free Interest Rate | 0.10%-4.49% | 0.04%-1.03% | ||
Expected Dividend Yield | 0% | 0% | ||
Expected Term (in years) | 2.04-5.86 | 2.02-5.86 |
The following charts show graphically the relationships over the past two years of the CAP Amounts for our PEO and Other NEOs as compared to our cumulative total shareholder return, or TSR, and net income:
We pay our non-employee directors a cash retainer for service on the board of directors and for service on each committee on which the director is a member pursuant to a director compensation program that was initially adopted by our board of directors effective upon completion of our initial public offering in July 2016. The chair of each committee and the chair of the board of directors receive higher retainers for such service. Effective January 1, 2020, the fees paid to non-employee directors for service on the board of directors and for service on each committee of the board of directors on which the director is a member are as follows:
Incremental— | Incremental— | |||||||||||
Base | Chair | Non-Chair | ||||||||||
Board of Directors | $ | 40,000 | $ | 30,000 | ||||||||
Audit Committee | $ | 15,000 | $ | 7,500 | ||||||||
Compensation Committee | $ | 10,000 | $ | 5,000 | ||||||||
Research and Development Committee | $ | 10,000 | $ | 5,000 | ||||||||
Nominating and Corporate Governance Committee | $ | 8,000 | $ | 4,000 |
In addition, under this director compensation program, we will grant to new non-employee directors upon their initial election to the board, an initial option to purchase 12,000 shares of our common stock, with an exercise price equivalent to fair market value of a share of common stock at the time of grant, which option will vest as to 16.66% of the shares on the six month anniversary of the date of grant and as to the remainder of the shares in equal monthly installments thereafter until the third anniversary of the date of grant, subject to continued service, with full acceleration upon a change in control of our company. The option will have a term of ten years. In addition, we will grant to new non-employee directors upon their initial election to the board, a restricted stock or restricted stock unit award (the form of such award being at the election of the director) for 8,000 shares of our common stock, which award will vest in equal annual installments until the third anniversary of the date of grant, subject to continued service, with full acceleration upon a change in control of our company. Prior to September
2022, the initial equity granted to non-employee directors upon their initial election to the board consisted of an option to purchase 3,500 shares of our common stock. In connection with this amendment to our director compensation program in September 2022, each of our continuing non-employee directors (Dr. Akkaraju, Mr. Alles, Dr. Dunsire, Dr. Eckhardt, Ms. Fanucci, Mr. Wirth and Dr. Young) were granted special equity awards equal to the same number of options and restricted stock or restricted stock unit awards that are granted to newly elected directors under the revised director compensation program.
Immediately following each annual meeting of our stockholders, we will grant to each non-employee director who has served on our board of directors for at least six months an option to purchase 6,000 shares of our common stock, with an exercise price equivalent to fair market value of a share of common stock at the time of grant, which option will vest as to 50% of the shares on the six-month anniversary of the date of grant and as to the remainder of the shares in equal monthly installments thereafter until the first anniversary of the date of grant, subject to continued service, with full acceleration upon a change in control of our company. The option will have a term of ten years. In addition, we will grant to each non-employee director who has served on our board of directors for at least six months a restricted stock or restricted stock unit award (the form of such award being at the election of the director) for 4,000 shares of our common stock, which award will vest in its entirety on the earlier to occur of (x) the first anniversary of the date of grant of the award or (y) the date of our next annual meeting of stockholders, subject in each case to continued service, with full acceleration upon a change in control of our company. Prior to September 2022, the annual equity granted to each non-employee director with at least six months of service on the board was an option to purchase 1,750 shares of our common stock.
We also reimburse our non-employee directors for reasonable travel and out-of-pocket expenses incurred in connection with attending our board of directors and committee meetings.
We do not pay any compensation to our president and chief executive officer in connection with her service on our board of directors. The compensation that we pay to our president and chief executive officer is discussed earlier in this “Executive Compensation” section.
The following table sets forth information regarding compensation earned by our non-employee directors during fiscal 2022.
Fees Earned or | Stock Awards | Option Awards | All Other Compensation | |||||||||||||||||
Name | Paid in Cash ($) | ($)(1) | ($)(1) | ($) | Total ($) | |||||||||||||||
Srinivas Akkaraju, M.D., Ph.D. | 49,000 | 58,792 | 72,492 | — | 180,284 | |||||||||||||||
Mark J. Alles | 47,500 | 58,792 | 72,492 | — | 178,784 | |||||||||||||||
Deborah Dunsire, M.D. | 50,000 | 58,792 | 72,492 | — | 181,284 | |||||||||||||||
S. Gail Eckhardt, M.D. | 50,454 | 58,792 | 72,492 | — | 181,738 | |||||||||||||||
Marsha H. Fanucci | 55,000 | 58,792 | 72,492 | — | 186,284 | |||||||||||||||
Amir Nashat, Ph.D. (2) | 39,514 | — | 9,426 | — | 48,940 | |||||||||||||||
Andrew M. Oh (3) | 13,811 | 58,792 | 63,066 | — | 135,669 | |||||||||||||||
Phillip A. Sharp, Ph.D. (4) | 35,498 | — | 9,426 | — | 44,924 | |||||||||||||||
Timothy C. Tyson (5) | 13,084 | 58,792 | 63,066 | — | 134,942 | |||||||||||||||
Peter Wirth | 80,000 | 58,792 | 72,492 | — | 211,284 | |||||||||||||||
Richard A. Young, Ph.D. | 50,872 | 58,792 | 72,492 | 57,500 | (6) | 239,656 |
(1) | The amounts reported in the “Stock Awards” and “Option Awards” columns reflect the aggregate grant date fair value of stock-based compensation awarded during the year computed in accordance with the provisions of ASC Topic 718. This calculation does not give effect to any estimate of forfeitures related to service-based vesting but assumes that the applicable director will perform the requisite service for the award to vest in full. See Note 13 to our financial statements included in our Annual Report on Form 10-K regarding assumptions underlying the valuation of equity awards. |
(2) | Dr. Nashat resigned from our board of directors in September 2022. |
(3) | Mr. Oh joined our board of directors in September 2022. |
(4) | Dr. Sharp resigned from our board of directors in September 2022. |
(5) | Mr. Tyson joined our board of directors in September 2022. |
(6) | Represents consideration paid during fiscal 2022 pursuant to the terms of a consulting agreement Dr. Young entered with our company that is unrelated to his service on our board of directors. |
As of December 31, 2022, our non-employee directors held the following stock and option awards, all of which were granted under our 2012 Equity Incentive Plan, as amended, or 2012 Plan, our 2016 Stock Incentive Plan, or 2016 Plan, and our 2022 Equity Incentive Plan, or the 2022 Plan:
Name | Stock Awards | Option Awards | ||||||
Srinivas Akkaraju, M.D., Ph.D. | 8,000 | 21,650 | ||||||
Mark J. Alles | 8,000 | 20,750 | ||||||
Deborah Dunsire, M.D. | 8,000 | 17,250 | ||||||
S. Gail Eckhardt, M.D. | 8,000 | 19,000 | ||||||
Marsha H. Fanucci | 8,000 | 24,216 | ||||||
Andrew M. Oh | 8,000 | 12,000 | ||||||
Timothy C. Tyson | 8,000 | 31,322 | ||||||
Peter Wirth | 8,000 | 21,650 | ||||||
Richard A. Young, Ph.D. | 8,000 | 30,250 |
Limitation of Liability and Indemnification
As permitted by Delaware law, we have adopted provisions in our certificate of incorporation that limit or eliminate the personal liability of our directors. Our certificate of incorporation limits the liability of directors to the maximum extent
23
permitted by Delaware law. Delaware law provides that directors of a corporation will not be personally liable for monetary damages for breaches of their fiduciary duties as directors, except liability for:
| any breach of the director’s duty of loyalty to us or our stockholders; |
| any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law; |
| any unlawful payments related to dividends or unlawful stock repurchases, redemptions or other distributions; or |
| any transaction from which the director derived an improper personal benefit. |
These limitations do not apply to liabilities arising under federal securities laws and do not affect the availability of equitable remedies, including injunctive relief or rescission. If Delaware law is amended to authorize the further elimination or limiting of a director, then the liability of our directors will be eliminated or limited to the fullest extent permitted by Delaware law as so amended.
As permitted by Delaware law, our certificate of incorporation also provides that:
| we will indemnify our directors and officers to the fullest extent permitted by law; |
| we may indemnify our other employees and other agents to the same extent that we indemnify our officers and directors, unless otherwise determined by our board of directors; and |
| we will advance expenses to our directors and officers in connection with legal proceedings to the fullest extent permitted by law. |
The indemnification provisions contained in our certificate of incorporation are not exclusive. In addition, we have entered into indemnification agreements with each of our directors and executive officers. Each of these indemnification agreements provides, among other things, that we will indemnify such director or executive
officer to the fullest extent permitted by law for claims arising in his or her capacity as a director or executive officer, as applicable, provided that he or she acted in good faith and in a manner that he or she reasonably believed to be in, or not opposed to, our best interests and, with respect to any criminal proceeding, had no reasonable cause to believe that his or her conduct was unlawful. Each of these indemnification agreements provides that in the event that we do not assume the defense of a claim against a director or executive officer, as applicable, we are required to advance his or her expenses in connection with his or her defense, provided that he or she undertakes to repay all amounts advanced if it is ultimately determined that he or she is not entitled to be indemnified by us.
We believe that these provisions and agreements are necessary to attract and retain qualified persons as directors and executive officers. Insofar as indemnification for liabilities arising under the Securities Act of 1933, as amended, or the Securities Act, may be permitted to directors, officers or persons controlling our company pursuant to the foregoing provisions, we understand that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.
In addition, we maintain standard policies of insurance under which coverage is provided to our directors and officers against losses arising from claims made by reason of breach of duty or other wrongful act, and to us with respect to payments which may be made by us to such directors and officers pursuant to the above indemnification provisions or otherwise as a matter of law.
24
Tax Considerations
Section 162(m) of the Internal Revenue Code, as amended, or the Code, generally disallows a tax deduction for compensation in excess of $1.0 million paid to certain of our officers. Certain compensation, including qualified performance-based compensation, will not be subject to the deduction limit if certain requirements are met. The compensation committee periodically reviews the potential consequences of Section 162(m) of the Code but may, in its judgment, authorize compensation payments that do not comply with exemptions in Section 162(m) when it believes that such payments are appropriate to attract and retain executive talent and are in the best interests of our stockholders.
Director Compensation
Our board of directors approved a director compensation program that became effective at the closing of our IPO in July 2016. Under this program, we pay our non‑employee directors a cash retainer for service on the board of directors and for service on each committee on which the director is a member. The chair of each committee and the chair of the board of directors receive higher retainers for such service. These fees are payable in arrears in four equal quarterly installments on the last day of each quarter, subject to proration for any portion of such quarter that the director is not serving on our board of directors, on such committee or in such position. The fees paid to non‑employee directors for service on the board of directors and for service on each committee of the board of directors on which the director is a member are as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
| Incremental— |
| Incremental— | |||
|
| Base |
| Chair |
| Non‑Chair | |||
Board of Directors |
| $ | 35,000 |
| $ | 30,000 |
|
|
|
Audit Committee |
|
|
|
| $ | 15,000 |
| $ | 7,500 |
Compensation Committee |
|
|
|
| $ | 10,000 |
| $ | 5,000 |
Nominating and Corporate Governance Committee |
|
|
|
| $ | 7,000 |
| $ | 3,500 |
In addition, under this director compensation program, we granted the directors who were in office at the time of the closing of our IPO, and will grant to new non-employee directors upon their initial election to the board, an initial option to purchase 22,000 shares of our common stock, with an exercise price equivalent to fair market value of a share of common stock at the time of grant, which option will vest as to 16.66% of the shares on the six month anniversary of the date of grant and as to the remainder of the shares monthly thereafter until the third anniversary of the date of grant, subject to continued service, with full acceleration upon a change in control of our company. The option will have a term of 10 years.
Immediately following each annual meeting of our stockholders, we will grant to each director who has served on our board of directors for at least six months an option to purchase 11,000 shares of our common stock, with an exercise price equivalent to fair market value of a share of common stock at the time of grant, which option will vest as to 50% of the shares on the six‑month anniversary of the date of grant and as to the remainder of the shares monthly thereafter until the first anniversary of the date of grant, subject to continued service, with full acceleration upon a change in control of our company. The option will have a term of 10 years.
We also reimburse our non‑employee directors for reasonable travel and out‑of‑pocket expenses incurred in connection with attending our board of directors and committee meetings.
We do not pay any compensation to our president and chief executive officer in connection with her service on our board of directors. The compensation that we pay to our president and chief executive officer is discussed earlier in this “Executive Compensation” section.
25
The following table sets forth information regarding compensation earned by our non-employee directors during fiscal 2016. Peter Wirth joined our board of directors in January 2017 and, therefore, did not earn any compensation during fiscal 2016.
|
|
|
|
|
|
|
|
| Fees Earned or |
| Option Awards |
|
|
Name |
| Paid in Cash ($) |
| ($)(1) |
| Total ($) |
Stéphane Bancel |
| 29,044 |
| 196,569 |
| 225,613 |
Marsha H. Fanucci |
| 24,626 |
| 196,569 |
| 221,195 |
Amir Nashat, Ph.D. |
| 20,703 |
| 196,569 |
| 217,272 |
Robert T. Nelsen |
| 35,522 |
| 196,569 |
| 232,091 |
Sanj K. Patel |
| 19,684 |
| 320,051 |
| 339,735 |
Vicki L. Sato, Ph.D. |
| 32,250 |
| 196,569 |
| 228,819 |
Phillip A. Sharp, Ph.D. |
| 31,250 |
| 196,569 |
| 227,819 |
Richard A. Young, Ph.D.(2) |
| 19,797 |
| 196,569 |
| 216,366 |
|
|
|
|
As of December 31, 2016, our non-employee directors held the following stock options, all of which were granted under our 2012 Equity Incentive Plan, as amended, or 2012 Plan, and our 2016 Stock Incentive Plan, or 2016 Plan:
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
|
26
SECURITIES AUTHORIZED FOR ISSUANCE UNDER EQUITY COMPENSATION PLANS
The following table contains information about our equity compensation plans as of December 31, 2016.2022. As of December 31, 2016,2022, we had threefour equity compensation plans each of which wasthat have been approved by our stockholders: ourstockholders (our 2012 Plan, our 2016 Plan, our 2022 Plan and our 2016 Employee Stock Purchase Plan, or 2016 ESPP.
ESPP), and one equity compensation plan that has not been approved by our stockholders (our 2022 Inducement Stock Incentive Plan, or Inducement Plan).
Equity Compensation Plan Information
|
|
|
|
|
|
|
|
|
|
| Number of |
|
|
|
| Number of securities |
|
|
| securities to be |
|
|
|
| remaining available for |
|
|
| issued upon |
|
|
|
| future issuance under |
|
|
| exercise of |
| Weighted average |
| equity compensation |
| |
|
| outstanding |
| exercise price of |
| plans (excluding |
| |
|
| options, warrants |
| outstanding options, |
| securities reflected in |
| |
Plan Category |
| and rights |
| warrants and rights (1) |
| column (a)) |
| |
|
| (a) |
| (b) |
| (c) |
| |
Equity compensation plans approved by security holders |
| 2,505,735 | (2) | $ | 6.53 |
| 3,255,918 | (3) |
Equity compensation plans not approved by security holders |
| 37,700 | (4) | $ | 0.04 |
| — |
|
Total |
| 2,543,435 |
| $ | 6.44 |
| 3,255,918 | (5) |
Plan Category | Number of securities to be issued upon exercise of outstanding options, warrants and rights | Weighted average exercise price of outstanding options, warrants and rights | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) | |||||||||
(a) | (b) | (c) | ||||||||||
Equity compensation plans approved by security holders | 2,695,057 | (1) | $ | 37.62 | 2,228,797 | (2) | ||||||
Equity compensation plans not approved by security holders | 188,557 | (3) | $ | 46.28 | 22,443 | (4) | ||||||
Total | 2,883,614 | $ | 38.17 | 2,251,240 | (5) |
(1) |
|
| Consists of (i) |
| (2) | Consists of (i) |
| (3) | Consists |
(4) |
|
|
(5) | Our 2016 ESPP has an evergreen provision that allows for an annual increase in the number of shares available for issuance under the 2016 ESPP to be added on the first day of each fiscal year |
27
REPORT OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS
Our audit committee has reviewed our audited consolidated financial statements for the fiscal year ended December 31, 20162022 and discussed them with our management and our independent registered public accounting firm, Ernst & Young LLP.
Our audit committee has also received from, and discussed with, Ernst & Young LLP various communications that Ernst & Young LLP is required to provide to our audit committee, including the matters required to be discussed by the statement on Auditing Standards No. 61, as amended (AICPA, Professional Standards, Vol. 1, AU section 380), as adopted byapplicable requirements of the Public Company Accounting Oversight Board in Rule 3200T.
and the Securities Exchange Commission.
In addition, Ernst & Young LLP provided our audit committee with the written disclosures and the letter required by applicable requirements of the Public Company Accounting Oversight Board regarding the independent registered public accounting firm’s communications with the audit committee concerning independence and has discussed with the Company’s independent registered public accounting firm their independence.
Based on the review and discussions referred to above, our audit committee recommended to our board of directors that the audited consolidated financial statements be included in our Annual Report on Form 10-K for the year ended December 31, 2016.
2023.
By the audit committee of the board of directors of Syros Pharmaceuticals, Inc.
Marsha H. Fanucci, Chair
Amir Nashat, Ph.D.Mark J. Alles
Sanj K. PatelAndrew M. Oh
28
MATTERS TO BE VOTED ON
Proposal 1: Election of Directors
Our certificate of incorporation provides for a classified board of directors. This means our board of directors is divided into three classes, with each class having as nearly as possible an equal number of directors. The term of service of each class of directors is staggered so that the term of one class expires at each annual meeting of the stockholders.
Our board of directors currently consists of ten members, divided into three classes as follows:
|
Class I is comprised of Mark J. Alles, Andrew M. Oh, Timothy C. Tyson and Peter Wirth, each with a term ending at the 2023 annual meeting of stockholders; |
|
Class II is comprised of Srinivas Akkaraju, M.D., Ph.D., Deborah Dunsire, M.D., and Richard A. Young, Ph.D., each with a term ending at the 2024 annual meeting of stockholders; and |
|
Class III is comprised of S. Gail Eckhardt, M.D., Marsha H. Fanucci and Nancy A. Simonian, M.D., each with a term ending at the 2025 annual meeting of stockholders. |
At each annual meeting of stockholders, directors are elected for a full term of three years to succeed those directors whose terms are expiring. Our board of directors, on the recommendation of our nominating and corporate governance committee, has set the number of directors at nineten and nominated Amir Nashat, Ph.D., Robert T. NelsenMark J. Alles, Andrew M. Oh, Timothy C. Tyson and Peter Wirth, for re-election as Class I directors, each with a term ending at the 20202026 annual meeting of stockholders. Mr. Bancel is not standing for re-election.
Unless otherwise instructed in the proxy or unless authority to vote is withheld, all executed proxies will be voted “FOR” the election of each of the Class I director nominees identified above to a three-year term ending at the 20202026 annual meeting of stockholders, each such nominee to hold office until his successor has been duly elected and qualified. Each of the nominees has indicated a willingness to continue to serve as director, if elected. In the event thatIf any nominee should be unable to serve, discretionary authority is reserved for the named proxy holders to vote for a substitute, or to reduce the number of directors to be elected, or both. We do not expect that any of the nominees will be unable to serve if elected.
A plurality of the combined voting power of the shares of common stock present in person or represented by proxy at the annual meeting and entitled to vote is required to elect each nominee as a director.
OUR BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE “FOR” THE ELECTION OF AMIR NASHAT, PH.D., ROBERT T. NELSENMARK J. ALLES, ANDREW M. OH, TIMOTHY C. TYSON AND PETER WIRTH, TO SERVE AS CLASS I DIRECTORS.
Proposal 2: Ratification of the Appointment of Independent Registered Public Accounting Firm
Our audit committee has appointed the firm of Ernst & Young LLP, or Ernst & Young,E&Y, an independent registered public accounting firm, as independent auditors for the fiscal year ending December 31, 2017.2023. Although stockholder approval of our audit committee’s appointment of Ernst & YoungE&Y is not required by law, our board of directors believes that it is advisable to give stockholders an opportunity to ratify this appointment. If this proposal is not approved at the annual meeting, our audit committee will reconsider its appointment of Ernst & Young. Ernst & YoungE&Y. E&Y has no direct or indirect material financial interest in our company or our subsidiaries. Representatives of Ernst & YoungE&Y are expected to be present atattend the virtual annual meeting and will have the opportunity to make a statement, if they desire to do so, and will be available to respond to appropriate questions from our stockholders.
29
Audit Fees and Services
Ernst & YoungE&Y was our independent registered public accounting firm for the years ended December 31, 20162022 and December 31, 2015.2021. The following table summarizes the fees of Ernst & YoungE&Y billed to us for each of the last two fiscal
years. All such services and fees were pre-approved by our audit committee in accordance with the “Pre-Approval“Pre-Approval Policies and Procedures” described below.
|
|
|
|
|
|
|
Fee Category |
| 2016 |
| 2015 | ||
Audit Fees (1) |
| $ | 475,141 |
| $ | 1,238,267 |
Audit-Related Fees (2) |
|
| — |
|
| — |
Tax Fees (3) |
|
| 11,300 |
|
| 12,000 |
All Other Fees (4) |
|
| 1,995 |
|
| 1,995 |
Total Fees |
| $ | 488,436 |
| $ | 1,252,262 |
Fee Category | 2022 | 2021 | ||||||
Audit Fees (1) | $ | 825,843 | $ | 590,640 | ||||
Audit-Related Fees | — | — | ||||||
Tax Fees (2) | 120,896 | 34,495 | ||||||
All Other Fees (3) | 2,000 | 2,000 | ||||||
|
|
|
| |||||
Total Fees | $ | 948,739 | $ | 627,135 | ||||
|
|
|
|
(1) | “Audit Fees” consist of fees for the audit of our annual financial statements, the review of the interim financial statements included in our quarterly reports on Form 10-Q, our |
(2) |
|
| “Tax Fees” consist of fees for professional services, including tax consulting and compliance performed by |
| (3) | “All Other Fees” consist of database subscription fees paid to |
Pre-Approval Policies and Procedures
Our audit committee has adopted procedures requiring the pre-approval of all non-audit services performed by our independent registered public accounting firm in order to assure that these services do not impair the auditor’s independence. These procedures generally approve the performance of specific services subject to a cost limit for all such services. This general approval is to be reviewed, and if necessary modified, at least annually. Management must obtain the specific prior approval of the audit committee for each engagement of the independent registered public accounting firm to perform other audit-related or other non-audit services. The audit committee does not delegate its responsibility to approve services performed by the independent registered public accounting firm to any member of management. Our audit committee has delegated authority to the committee chair to pre-approve any audit or non-audit service to be provided to us by our independent registered public accounting firm provided that the fees for such services do not exceed $100,000. Any approval of services by the committee chair pursuant to this delegated authority must be reported to the audit committee at the next meeting of the committee.
The standard applied by the audit committee, or the chair of the audit committee, in determining whether to grant approval of any type of non-audit service, or of any specific engagement to perform a non-audit service, is whether the services to be performed, the compensation to be paid therefore and other related factors are consistent with the independent registered public accounting firm’s independence under guidelines of the SEC and applicable professional standards. Relevant considerations include whether the work product is likely to be subject to, or implicated in, audit procedures during the audit of our financial statements, whether the independent registered public accounting firm would be functioning in the role of management or in an advocacy role, whether the independent registered public accounting firm’s performance of the service would enhance our ability to manage or control risk or improve audit quality, whether such performance would increase efficiency because of the independent registered public accounting firm’s familiarity with our business, personnel, culture, systems, risk profile and other factors, and whether the amount of fees involved, or the non-audit services portion of the total fees payable to the independent registered public accounting firm in the period would tend to reduce the independent registered public accounting firm’s ability to exercise independent judgment in performing the audit.
OUR BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE “FOR” THE RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2017.2023.
Proposal 3: Advisory Vote on Executive Compensation
We are providing our stockholders the opportunity to vote to approve, on an advisory, non-binding basis, the compensation of our named executive officers as disclosed in this proxy statement in accordance with the SEC’s rules. This proposal, which is commonly referred to as “say-on-pay,” is required by the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, or the Dodd-Frank Act, which added Section 14A to the Securities Exchange Act of 1934, or the Exchange Act. Our executive compensation program is designed to reward value creation for stockholders and to attract, motivate, and retain our executive officers, who are critical to our success. Under this program, our named executive officers are rewarded for the achievement of our short- and long-term strategic and financial goals, which we believe serves to enhance short- and long-term value creation for our stockholders. The program contains elements of cash and equity-based compensation and are designed to align the interests of our executives with those of our stockholders and paying for performance.
The section of this proxy statement titled “Executive and Director Compensation” beginning on page 21 including “Narrative Disclosure to Summary Compensation Table,” describes in detail our executive compensation program and the decisions made by our compensation committee. Our executive compensation program rewards value creation for stockholders and progress towards achieving our mission and that promotes company performance. At the same time, we believe our program does not encourage excessive risk-taking by management. While we do not have a formal or informal policy for allocating between long-term and short-term compensation, between cash and non-cash compensation or among different forms of non-cash compensation, we generally strive to provide our named executive officers with a mix of short-term and long-term performance-based incentives to encourage consistently strong performance, and our board of directors believes that this link between compensation and the achievement of our near- and long-term business goals has helped drive our performance over time.
Our board of directors is asking stockholders to approve a non-binding advisory vote on the following resolution:
RESOLVED, that the compensation paid to the Company’s named executive officers, as disclosed pursuant to the compensation disclosure rules of the Securities and Exchange Commission, including the compensation tables and any related material disclosed in this proxy statement, is hereby approved.
As an advisory vote, this proposal is not binding. The outcome of this advisory vote will not overrule any decision by the company or the board of directors (or any committee thereof), create or imply any change to the fiduciary duties of the company or the board of directors (or any committee thereof), or create or imply any additional fiduciary duties for the company or the board of directors (or any committee thereof). However, our compensation committee and board of directors value the opinions expressed by our stockholders in their vote on this proposal and intend to consider carefully the outcome of the vote when making future compensation decisions for named executive officers.
OUR BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE TO APPROVE THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS BY VOTING “FOR” THIS PROPOSAL.
30
STOCK OWNERSHIP AND REPORTING
Security Ownership of Certain Beneficial Owners and Management
Unless otherwise provided below, the following table sets forth information regarding beneficial ownership of our common stock as of April 1, 20177, 2023 by:
| each person, or group of affiliated persons, known to us to be the beneficial owner of 5% or more of the outstanding shares of our common stock; |
| each of our current directors; |
|
|
| all of our current executive officers and directors as a group. |
Beneficial ownership is determined in accordance with the rules and regulations of the SEC and includes voting or investment power with respect to our common stock. Percentage of beneficial ownership is based on 23,436,28120,409,130 shares of our common stock outstanding as of April 1, 2017.7, 2023. In addition, shares of common stock subject to options or other rights currently exercisable, or exercisable within 60 days of April 1, 2017,7, 2023, are deemed outstanding and beneficially owned for the purpose of computing the percentage beneficially owned by (i) the individual holding such options, warrants or other rights (but not any other individual) and (ii) the directors and executive officers as a group. Except as otherwise noted, the persons and entities in this table have sole voting and investing power with respect to all of the shares of our common stock beneficially owned by them, subject to community property laws, where applicable. Except
31
as otherwise set forth below, the address of the beneficial owner is c/o Syros Pharmaceuticals, Inc., 620 Memorial35 CambridgePark Drive, Suite 300,4th Floor, Cambridge Massachusetts 02139.02140.
Total Beneficial Ownership | ||||||||||||||||||||||||
Name of Beneficial Owner | Shares of Common Stock Beneficially Owned | + | Common Stock Underlying Options and Other Rights Acquirable Within 60 Days | = | Shares Beneficially Owned | Percentage of Shares Beneficially Owned | ||||||||||||||||||
5% Stockholders | ||||||||||||||||||||||||
Entities affiliated with Avidity Capital Partners | 900,000 | (1) | 1,265,272 | (2) | 2,165,272 | 9.99 | % | |||||||||||||||||
Deep Track Biotechnology Master Fund, Ltd. | — | 2,265,161 | (3) | 2,265,161 | 9.99 | % | ||||||||||||||||||
Entities affiliated with Bain Capital Life Sciences, L.P. | 1,082,404 | (4) | 1,062,624 | (5) | 2,145,028 | 9.99 | % | |||||||||||||||||
Entities affiliated with Invus Public Equities, L.P. | 1,463,829 | (6) | 638,865 | (7) | 2,102,694 | 9.99 | % | |||||||||||||||||
Samsara BioCapital, L.P. | 881,450 | (8) | 707,114 | (9) | 1,588,564 | 7.52 | % | |||||||||||||||||
Ally Bridge MedAlpha Master Fund L.P. | 868,403 | (10) | 570,976 | (11) | 1,439,379 | 6.86 | % | |||||||||||||||||
Adage Capital Partners LP | 721,914 | (12) | 531,914 | (13) | 1,253,828 | 5.99 | % | |||||||||||||||||
CHI IV Public Investments LP | 531,914 | (14) | 531,914 | (15) | 1,063,828 | 5.08 | % | |||||||||||||||||
Named Executive Officers and Directors | ||||||||||||||||||||||||
Nancy Simonian, M.D. | 89,420 | (16) | 151,519 | 240,939 | 1.17 | % | ||||||||||||||||||
David A. Roth, M.D. | 7,348 | 61,940 | 69,288 | * | % | |||||||||||||||||||
Eric R. Olson, Ph.D. | 7,350 | 43,902 | 51,252 | * | % | |||||||||||||||||||
Srinivas Akkaraju, M.D., Ph.D. | 881,450 | (8) | 719,429 | (17) | 1,600,879 | 7.58 | % | |||||||||||||||||
Mark J. Alles | 1,000 | 11,415 | 12,415 | * | % | |||||||||||||||||||
Deborah Dunsire, M.D. | 8,000 | 6,359 | 14,359 | * | % | |||||||||||||||||||
S. Gail Eckhardt, M.D. | 8,000 | 9,275 | 17,275 | * | % | |||||||||||||||||||
Marsha H. Fanucci | 8,000 | 14,881 | 22,881 | * | % | |||||||||||||||||||
Andrew M. Oh | 8,000 | 2,665 | 10,665 | * | % | |||||||||||||||||||
Timothy C. Tyson | 25,189 | 21,987 | 47,176 | * | % | |||||||||||||||||||
Peter Wirth | 8,000 | 12,315 | 20,315 | * | % | |||||||||||||||||||
Richard A. Young, Ph.D. | 32,171 | 13,415 | 45,586 | * | % | |||||||||||||||||||
All Current Executive Officers and Directors as a Group (16 persons) | 1,099,812 | 1,154,251 | 2,254,063 | 10.45 | % |
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| Total Beneficial Ownership |
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| Common Stock |
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| Shares of |
| Underlying |
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| Percentage |
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| Common Stock |
| Options and Other |
| Shares |
| of Shares |
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| Beneficially | + | Rights Acquirable | = | Beneficially |
| Beneficially |
|
Name of Beneficial Owner |
| Owned |
| Within 60 Days |
| Owned |
| Owned |
|
5% Stockholders |
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Entities affiliated with Flagship Ventures |
| 4,806,656 |
| — |
| 4,806,656 | (1) | 20.5 | % |
ARCH Venture Fund VII, L.P. |
| 4,637,137 |
| — |
| 4,637,137 | (2) | 19.8 | % |
Entities affiliated with FMR LLC |
| 3,507,070 |
| — |
| 3,507,070 | (3) | 15.0 | % |
Entities affiliated with Deerfield Management |
| 1,812,778 |
| — |
| 1,812,778 | (4) | 7.7 | % |
Entities affiliated with Polaris |
| 1,586,653 |
| — |
| 1,586,653 | (5) | 6.8 | % |
Named Executive Officers and Directors |
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Nancy Simonian, M.D. |
| 530,700 | (6) | 125,416 |
| 656,116 |
| 2.8 | % |
Kyle D. Kuvalanka |
| — |
| 106,376 |
| 106,376 |
| * |
|
Gerald E. Quirk, Esq. |
| — |
| — |
| — |
| — |
|
David A. Roth, M.D. |
| — |
| 60,394 |
| 60,394 |
| * |
|
Stéphane Bancel |
| 47,980 |
| 7,943 |
| 55,923 |
| * |
|
Marsha H. Fanucci |
| — |
| 10,693 |
| 10,693 |
| * |
|
Amir Nashat, Ph.D. |
| 1,586,653 | (7) | 4,889 |
| 1,591,542 |
| 6.8 | % |
Robert T. Nelsen |
| 4,637,137 | (8) | 4,889 |
| 4,642,026 |
| 19.8 | % |
Sanj K. Patel |
| — |
| 4,889 |
| 4,889 |
| * |
|
Vicki L. Sato, Ph.D. |
| — |
| 24,593 |
| 24,593 |
| * |
|
Phillip A. Sharp, Ph.D. |
| 266,666 | (9) | 43,467 |
| 310,133 |
| 1.3 | % |
Peter Wirth |
| — |
| — |
| — |
| — |
|
Richard A. Young, Ph.D. |
| 426,665 |
| 4,889 |
| 431,554 |
| 1.8 | % |
All Executive Officers and Directors as a Group (14 persons) |
| 7,495,801 |
| 559,765 |
| 8,055,566 |
| 33.6 | % |
*Represents beneficial ownership of less than 1% of our outstanding stock.
* | Represents beneficial ownership of less than 1% of our outstanding stock. |
(1) |
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32
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(2) |
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(3) |
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(4) | Bain Capital Life Sciences Fund II, L.P. |
Entities. The address of |
(5) |
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(6) | Invus Public Equities, L.P. (“Invus Public Equities”) directly holds 1,463,829 shares of common stock. Invus Public Equities Advisors, LLC (“Invus PE Advisors”), as the general partner of Invus Public Equities, controls Invus Public Equities and, accordingly, may be deemed to beneficially own the shares held by Invus Public Equities. The Geneva branch of Artal International S.C.A (“Artal International”), as the managing member of Invus PE Advisors, controls Invus PE Advisors, and, accordingly, may be deemed to beneficially own the shares that Invus PE Advisors may be deemed to beneficially own. Artal International Management S.A. (“Artal International Management”), as the managing partner of Artal International, controls Artal International and, accordingly, may be deemed to beneficially own the shares that Artal International may be deemed to beneficially own. Artal Group S.A. (“Artal Group”), as the sole stockholder of Artal International Management, controls Artal International Management and, accordingly, may be deemed to beneficially own the shares that Artal International Management may be deemed to beneficially own. Westend S.A. (“Westend”), as the parent company of Artal Group, controls Artal Group and, accordingly, may be deemed to beneficially own the shares that Artal Group may be deemed to beneficially own. Stichting Administratiekabntoor Westland (“Stichting”), as the majority stockholder of Westend, controls Westend and, accordingly, may be deemed to beneficially own the shares that Westend may be deemed to beneficially own. Mr. Amaury Wittouck (“Mr. Wittouck”), as the sole member of the board of the Stichting, controls the Stichting and, accordingly, may be deemed to beneficially own the shares that the Stichting may be deemed to beneficially own. The address for Invus Public Equities and Invus PE Advisors is 750 Lexington Avenue, 30th Floor, New York, NY 10022. The address for Artal International, Artal International Management, Artal Group, Westend and Mr. Wittouck is Valley Park, 44, Rue de la Vallée, L-2661, Luxembourg. The address for Stichting is Claude Debussylaan, 46, 1082 MD Amsterdam, The Netherlands. For information regarding Invus Public Equities, Invus PE Advisors, Artal International, Artal International Management, Artal Group, Westend, Stichting, and Mr. Wittouck, we have relied, without independent investigation, on the Schedule 13G/A filed by such parties with the SEC on February 13, 2023. |
(7) | Invus Public Equities directly holds warrants to purchase 1,063,829 shares of common stock. Such warrants may not be exercised if, as a result of such exercise, Invus Public Equities, together with its affiliates and certain other persons for whom beneficial ownership would be aggregated, would beneficially own more than 9.99% of the total number of shares then issued and outstanding immediately after giving effect to the exercise. For information regarding Invus Public Equities, we have relied, without independent investigation, on the Schedule 13G/A filed by such parties with the SEC on February 13, 2023. |
(8) | Consists of 881,450 shares of common stock owned by Samsara BioCapital, L.P. (“Samsara LP”). The general partner of Samsara LP is Samsara BioCapital GP, LLC (“Samsara LLC”). The managers of Samsara LLC are Srinivas Akkaraju and Michael Dybbs. These individuals may be deemed to have shared voting and investment power of the shares held by Samsara LP and may be deemed to beneficially own certain shares held by Samsara LP. Dr. Akkaraju disclaims beneficial ownership of these shares, except to the extent of his pecuniary interest therein. |
(9) | Consists of warrants to purchase shares of common stock that are owned by Samsara LP and are currently exercisable. Dr. Akkaraju disclaims beneficial ownership of such warrants and the shares of common stock |
underlying them, except to the extent of his pecuniary interest therein. |
(10) |
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(11) | Consists of warrants to purchase shares of common stock that are owned by Ally Bridge and are currently exercisable. For information regarding Ally Bridge, we have relied, without independent investigation, on the Schedule 13G/A filed by Ally Bridge with the SEC on January 30, 2023. |
(12) | Adage Capital Partners, L.P. reports direct ownership with respect to all of the shares listed herein. Bob Atchinson and Phillip Gross are the managing members of Adage Capital Advisors, L.L.C., which is the managing member of Adage Capital Partners GP, L.L.C., which is the general partner of Adage Capital Partners, L.P., and each such person or entity, as the case may be, may be deemed the beneficial owner of such shares. The address of Adage Capital Partners, L.P. is 200 Clarendon Street, 52nd Floor, Boston MA 02116. For information regarding the foregoing individual and entities, we have relied, without independent investigation, on the Schedule 13G filed by such individuals and entities with the SEC on January 25, 2023. |
(13) | Consists of warrants to purchase shares of common stock that are owned by Adage Capital Partners, L.P. and are currently exercisable. For information regarding Adage Capital Partners, L.P., we have relied, without independent investigation, on the Schedule 13G filed by Adage Capital Partners, L.P. with the SEC on January 25, 2023. |
(14) | CHI IV Public Investments LP (“CHI IV”) directly owns the shares of common stock listed herein. CHI Advisors LLC, the investment adviser of CHI IV has sole voting and investment power with respect to the shares owned by CHI IV. The address for CHI Advisors, LLC and CHI IV is 599 Lexington Avenue, 19th Floor, New York, NY 10022. |
(15) | Consists of warrants to purchase shares of common stock that are owned by CHI IV and are currently exercisable. |
(16) | Consists of (i) |
(17) |
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33
Delinquent Section 16(a) Beneficial Ownership Reporting Compliance
Reports
Section 16(a) of the Exchange Act requires our directors and executive officers, and holders ofpersons who own more than 10%ten percent of a registered class of our common stockequity securities, to file with the SEC initial reports of ownership and reports of changes in ownership of our common stock and other equity securities on a Form 3securities. Officers, directors and reports of changes in such ownership on a Form 4 or Form 5. Directors and officers and holders of 10% of our common stockgreater than ten percent stockholders are required by SEC regulationsregulation to furnish us with copies of all Section 16(a) forms they file.
To our knowledge, based solely on a review of our recordsthe copies of such reports furnished to us and written representations made by our directors and officers regarding their filing obligations,that no other reports were required, during the fiscal year ended December 31, 2022, all Section 16(a) filing requirements applicable to its officers, directors and greater than ten percent beneficial owners were satisfiedcomplied with, respectexcept that one Form 4 reflecting one transaction was not reported on a timely basis for each of Srinivas Akkaraju, M.D., Ph.D., and Timothy C. Tyson, due to fiscal 2016.an administrative oversight.
As of the date of this proxy statement, we know of no matter not specifically referred to above as to which any action is expected to be taken at the annual meeting. The persons named as proxies will vote the proxies, insofar as they are not otherwise instructed, regarding such other matters and the transaction of such other business as may be properly brought before the meeting, as seems to them to be in the best interest of our company and our stockholders.
Stockholder Proposals for our 20182024 Annual Meeting
Stockholder Proposals Included in Proxy Statement
In order to be considered for inclusion in our proxy statement and proxy card relating to our 20182024 annual meeting of stockholders, stockholder proposals must be received by us no later than December 26, 2017,23, 2023, which is 120 days prior to the first anniversary of the mailing date of this proxy, unless the date of the 20182024 annual meeting of stockholders is changed by more than 30 days from the anniversary of our 20172023 annual meeting, in which case, the deadline for such proposals will be a reasonable time before we begin to print and send our proxy materials. Upon receipt of any such proposal, we will determine whether or not to include such proposal in the proxy statement and proxy card in accordance with regulations governing the solicitation of proxies.
Stockholder Proposals Not Included in Proxy Statement
In addition, our by-laws establish an advance notice procedure for nominations for election to our board of directors and other matters that stockholders wish to present for action at an annual meeting other than those to be included in our proxy statement. In general, we must receive other proposals of stockholders (including director nominations) intended to be presented at the 20182024 annual meeting of stockholders but not included in the proxy statement by March 10, 2018,3, 2024, but not before February 8, 2018,2, 2024, which is not less than 90 days nor more than 120 days prior to the anniversary date of the immediately preceding annual meeting. However, if the date of the annual meeting is more than 30 days before or more than 60 days after such anniversary date, notice must be received no earlier than the close of business 120 calendar days prior to such annual meeting and no later than the close of business on the later of 90 days prior to such annual meeting and 10 days following the day on which notice of the date of such annual meeting was mailed or public announcement of the date of such annual meeting was first made. If the stockholder fails to give notice by these dates, then the persons named as proxies in the proxies solicited by the board of directors for the 20182024 annual meeting of stockholders may exercise discretionary voting power regarding any such proposal. Stockholders are advised to review our by-laws which also specify requirements as to the form and content of a stockholder’s notice.
In addition to satisfying the advance notice provisions in our by-laws relating to director nominations, including the earlier notice deadlines set out above, in order to comply with the SEC’s universal proxy rule, stockholders who intend to solicit proxies in support of director nominees other than the Company’s nominees in compliance with Rule 14a-19 under the Exchange Act must also provide notice that sets forth the information required by Rule 14a-19 no later than April 2, 2024. If the date of the 2024 annual meeting of stockholders changes by more than 30 calendar days from the anniversary of our 2023 annual meeting, such notice must instead be provided by the later of 60 calendar days prior to the date of the 2024 annual meeting of stockholders or the 10th calendar day following our public announcement of the date of the 2024 annual meeting of stockholders.
Any proposals, notices or information about proposed director candidates should be sent to Syros Pharmaceuticals, Inc., Attention: Nominating and Corporate Governance Committee, 620 Memorial35 CambridgePark Drive, Suite 300,4th Floor, Cambridge, Massachusetts 02139.02140.
34
Householding of Annual Meeting Materials
Some brokers and other nominee record holders may be “householding” our proxy materials. This means a single notice and, if applicable, the proxy materials, will be delivered to multiple stockholders sharing an address unless
contrary instructions have been received. We will promptly deliver a separate copy of the notice and, if applicable, the proxy materials and our 20162022 annual report to stockholders, which consists of our Annual Report on Form 10-K for the fiscal year ended December 31, 2016,2022, to you if you write or call us at Syros Pharmaceuticals, Inc., 620 Memorial35 CambridgePark Drive, 4th Floor, Cambridge, Massachusetts 02139,02140, Attention: Chief OperatingFinancial Officer, telephone: (617) 744-1340. If you would like to receive separate copies of our proxy materials and annual reports in the future, or if you are receiving multiple copies and would like to receive only one copy for your household, you should contact your bank, broker, or other nominee record holder, or you may contact us at the above address and telephone number.
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TableSYRS VOTE 000004 ENDORSEMENT_LINE SACKPACK MR A SAMPLE DESIGNATION (IF ANY) ADD 1 ADD 2 ADD 3 ADD 4 ADD 5 ADD 6 Using a black ink pen, mark your votes with an X as shown in this example. Please do not write outside the designated areas. C123456789 000000000.000000 ext 000000000.000000 ext 000000000.000000 ext 000000000.000000 ext 000000000.000000 ext 000000000.000000 ext Your vote matters – here’s how to vote! You may vote online or by phone instead of Contentsmailing this card. Online Go to www.envisionreports.com/SYRS or scan the QR code – login details are located in the shaded bar below. Phone Call toll free 1-800-652-VOTE
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02IYFD
2017 (8683) within the USA, US territories and Canada Save paper, time and money! Sign up for electronic delivery at www.envisionreports.com/SYRS 2023 Annual Meeting Admission Ticket
2017 Annual Meeting of
Syros Pharmaceuticals, Inc. Stockholders
Thursday, June 8, 2017, 1:00 p.m. Eastern Time
620 Memorial Drive, Suite 300
Cambridge, Massachusetts 02139
Upon arrival, please present this admission ticket
and photo identification at the registration desk.
Proxy Card 1234 5678 9012 345 IF YOU HAVE NOT VOTED VIA THE INTERNET OR TELEPHONE, FOLD ALONG THE PERFORATION,VOTING BY MAIL, SIGN, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE. A Proposals – The Board of Directors recommends a vote FOR all the nominees listed in Proposal 1, FOR Proposals 2 and 3. Election of four Class I directors, each to serve for a three-year term expiring at the Company’s 2026 annual meeting of stockholders and until her successor has been duly elected and qualified. + For Withhold 01 - Mark J. Alles [ ] [ ] For Withhold 02 - Andrew M. Oh [ ] [ ] For Withhold 03 - Timothy C. Tyson [ ] [ ] 04 - Peter Wirth [ ] [ ] For Against Abstain 2. Ratification of the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2023. [ ] [ ] [ ] For Against Abstain 3. Approval, on a non-binding advisory basis, of the compensation of the Company’s named executive officers. [ ] [ ] [ ] B Authorized Signatures – This section must be completed for your vote to count. Please date and sign below. Please sign exactly as name(s) appears hereon. Joint owners should each sign. When signing as attorney, executor, administrator, corporate officer, trustee, guardian, or custodian, please give full title. Date (mm/dd/yyyy) – Please print date below. Signature 1 – Please keep signature within the box. Signature 2 – Please keep signature within the box. C 1234567890 42BV J N T 574073 MR A SAMPLE (THIS AREA IS SET UP TO ACCOMMODATE 140 CHARACTERS) MR A SAMPLE AND MR A SAMPLE AND MR A SAMPLE AND MR A SAMPLE AND MR A SAMPLE AND MR A SAMPLE AND MR A SAMPLE AND MR A SAMPLE AND + 03S0AA
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Notice of 2017The 2023 Annual Meeting of Stockholders
620 Memorial Drive, Suite 300, Cambridge, MA 02139
of Syros Pharmaceuticals, Inc. will be held on Thursday, June 1, 2023, 9:00 a.m. local time, virtually via the internet at meetnow.global/MQZFQ4S. To access the virtual meeting, you must have the information that is printed in the shaded bar located on the reverse side of this form. Small steps make an impact. Help the environment by consenting to receive electronic delivery, sign up at www.envisionreports.com/SYRS IF VOTING BY MAIL, SIGN, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE. Proxy – Syros Pharmaceuticals, Inc. + Notice of 2023 Annual Meeting of Stockholders Proxy Solicited by Board of Directors for Annual Meeting -– Thursday, June 8, 2017
1, 2023 Nancy A. Simonian, Kyle D. Kuvalanka, Gerald E. Quirk, or anyeither of them (the “Proxies”), each with the power of substitution, are hereby authorized to represent and vote the shares of the undersigned, with all the powers which the undersigned would possess if personally present, at the Annual Meeting of Stockholders of Syros Pharmaceuticals, Inc. to be held virtually via the internet on June 8, 20171, 2023 or at any postponement or adjournment thereof.
Shares represented by this proxy will be voted by the stockholder. If no such directions are indicated, the Proxies will have authority to vote FOR each of the nominees listed in Proposal 1, FOR Proposals 2 and FOR Item 2.
3. In their discretion, the Proxies are authorized to vote upon such other business as may properly come before the meeting.
(Itemsmeeting or at any postponement or adjournment thereof. (Items to be voted appear on reverse side.)side) C Non-Voting Items Change of Address – Please print new address below. Comments – Please print your comments below. +